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proTAME

Cat. No. 7734 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cell-permeable APC/C inhibitor
化学名： Methyl (2S)-2-[[(4-methylphenyl)sulfonyl]amino]-9,13-dioxo-14-phenyl-7-[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]-10,12-dioxa-6,8-diazatetradec-6-enoate
纯度： ≥90% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for proTAME

ProTAME is a cell-permeable APC/C (anaphase-promoting complex/cyclosome) inhibitor. It is converted to TAME (Tosyl-L-Arginine Methyl Ester) by intracellular esterases. It induces cell cycle arrest in metaphase followed by cell death.

技术数据 for proTAME

分子量 726.75
公式 C34H38N4O12S
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 1362911-19-0
PubChem ID 56924780
InChI Key MHYOVHULCQSDRZ-NDEPHWFRSA-N
Smiles O=C([C@@H](NS(=O)(C1=CC=C(C=C1)C)=O)CCC/N=C(NC(OCOC(CC2=CC=CC=C2)=O)=O)/NC(OCOC(CC3=CC=CC=C3)=O)=O)OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for proTAME

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.34 50

制备储备液 for proTAME

以下数据基于产品分子量 726.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 2.75 mL 13.76 mL 27.52 mL
2.5 mM 0.55 mL 2.75 mL 5.5 mL
5 mM 0.28 mL 1.38 mL 2.75 mL
25 mM 0.06 mL 0.28 mL 0.55 mL

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参考文献 for proTAME

参考文献是支持产品生物活性的出版物。

Zeng et al (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 18 382 PMID: 20951947

If you know of a relevant reference for proTAME, please let us know.

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关键词: proTAME, proTAME supplier, cell, cycle, meiosis, mitosis, anaphase, promoting, complex, cyclosome, metaphase, TAME, apoptosis, cell-permeable, Mitosis, 7734, Tocris Bioscience

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Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.