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ProTx I

Cat. No. 4665 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4665 has been discontinued.

View all Ca<sub>V</sub>3.x Channels (T-type) products.
说明： CaV3.1 blocker; also inhibits NaV1.8 and KV2.1
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for ProTx I

ProTx I is a selective CaV3.1 channel blocker (IC50 values are 0.2 and 31.8 μM for hCaV3.1 and hCaV3.2 respectively). Also reversibly inhibits NaV1.8 and blocks KV2.1 channels.

技术数据 for ProTx I

分子量 3987.51
公式 C171H245N53O47S6
序列 ECRYWLGGCSAGQTCCKHLVCSRRHGWCVWDGTFS

(Modifications: Disulfide bridge: 2-16, 9-21, 15-28)

储存 Store at -20°C
CAS Number 484598-35-8
PubChem ID 90488963
InChI Key TYAZSKURKBASCY-UHFFFAOYSA-N
Smiles [H]N[C@@H](CCC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)CNC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N3)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCCCN)NC2=O)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for ProTx I

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ProTx I

参考文献是支持产品生物活性的出版物。

Ohkubo et al (2010) Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ channels Cav3.1 and Cav3.2. J.Pharmacol.Sci. 112 452 PMID: 20351484

Ohkubo and Yamazaki (2012) T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells. Int.J.Oncol. 41 267 PMID: 22469755

Middleton et al (2002) Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry 41 14734 PMID: 12475222

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关键词: ProTx I, ProTx I supplier, ProTxI, calcium, sodium, potassium, ion, channels, NaV1.8, CaV3.1, CaV3.2, KV2.1, selective, blockers, venoms, Cav3.x, Channels, Voltage-gated, Sodium, Voltage-Gated, Potassium, 4665, Tocris Bioscience

篇 ProTx I 的引用文献

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