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Submit ReviewPRX 07034
说明： Potent and selective 5-HT6 antagonist
化学名： N-(1-(5-Chloro-2,3-dimethoxyphenyl)ethyl)-2-(methylsulfonyl)-5-(piperazin-1-yl)aniline hydrochloride
纯度： ≥98% (HPLC)
生物活性 for PRX 07034
PRX 07034 is a potent and selective 5-HT6 receptor antagonist (IC50 = 19 nM, Ki = 4 - 8 nM). Enhances working memory in rats.
化合物库 for PRX 07034
PRX 07034 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for PRX 07034
| 分子量 | 490.44 |
| 公式 | C21H28ClN3O4S.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 903580-39-2 |
| PubChem ID | 23653584 |
| InChI Key | PILCQJJJAFRKHO-UHFFFAOYSA-N |
| Smiles | ClC1=CC(C(NC2=C(S(C)(=O)=O)C=CC(N3CCNCC3)=C2)C)=C(OC)C(OC)=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PRX 07034
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 9.81 | 20 温和加热 | |
| DMSO | 49.04 | 100 |
制备储备液 for PRX 07034
以下数据基于产品分子量 490.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.19 mL | 20.39 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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产品说明书 for PRX 07034
参考文献 for PRX 07034
参考文献是支持产品生物活性的出版物。
Mohler et al (2012) The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 220 687 PMID: 21989804
If you know of a relevant reference for PRX 07034, please let us know.
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关键词: PRX 07034, PRX 07034 supplier, PRX07034, potent, selective, serotonergic, 5HT6, receptor, 5-HT, antagonists, antagonism, 5-HT6, Receptors, 6748, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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