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PSB 0788

Cat. No. 3199 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective A2B antagonist
化学名： 8-[4-[4-(4-Chlorobenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PSB 0788

PSB 0788 is a potent and selective adenosine A2B receptor antagonist (IC50 = 3.64 nM at human A2B receptors). Displays > 100-fold selectivity over hA1, hA2A and hA3 receptors.

化合物库 for PSB 0788

PSB 0788 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PSB 0788

分子量 543.04
公式 C25H27ClN6O4S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1027513-54-7
PubChem ID 44186581
InChI Key JQZJACVYMPKVDS-UHFFFAOYSA-N
Smiles O=C(NC2=C1NC(C3=CC=C(S(N4CCN(CC5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PSB 0788

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 54.3 100

制备储备液 for PSB 0788

以下数据基于产品分子量 543.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.21 mL 18.41 mL
5 mM 0.37 mL 1.84 mL 3.68 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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参考文献 for PSB 0788

参考文献是支持产品生物活性的出版物。

Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717

If you know of a relevant reference for PSB 0788, please let us know.

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关键词: PSB 0788, PSB 0788 supplier, Selective, A2B, antagonists, Receptors, adenosines, PSB0788, Adenosine, 3199, Tocris Bioscience

2 篇 PSB 0788 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PSB 0788 的部分引用包括：

Al-Taei et al (2017) Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer. Oncoimmunology 6 e1268308 PMID: 28344879

Wakisaka et al (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol 27 1437 PMID: 28502661

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