PSB 11 hydrochloride

Name: PSB 11 hydrochloride
Brand: Tocris Bioscience
SKU: 2012

Cat. No. 2012 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2012 has been discontinued.

View all Adenosine A<sub>3</sub> Receptors products.

说明： Potent, selective hA₃ receptor antagonist/inverse agonist

化学名： (8R)-8-Ethyl-1,4,7,8-tetrahydro-4-5H-imidazo[2,1-i]purin-5-one hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for PSB 11 hydrochloride

PSB 11 hydrochloride is a potent and selective antagonist for the human adenosine A₃ receptor, with low affinity for the rat A₃ receptor (K_i values are 2.3 and > 10000 nM respectively). Displays > 1000-fold selectivity over human A₁ and A_2A receptors (K_i values are 4.1 and 3.3 μM respectively) and > 180-fold selectivity over rat A₁, rat A_2A and mouse A_2B receptors. Acts as an inverse agonist in the [³⁵S]GTPγS binding assay in hA₃-CHO cells (IC₅₀ = 36 nM).

技术数据 for PSB 11 hydrochloride

分子量	331.8
公式	C₁₆H₁₇N₅O.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	453591-58-7
PubChem ID	16759152
InChI Key	JAUSHKIWPLHBCN-RFVHGSKJSA-N
Smiles	Cl[H].CC[C@@H]1CN2C(=N1)C1=C(N=C(N1)C1=CC=CC=C1)N(C)C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PSB 11 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PSB 11 hydrochloride

参考文献是支持产品生物活性的出版物。

Muller et al (2002) Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A_2A- and A₃-adenosine receptor antagonists. J.Med.Chem. 45 3440 PMID: 12139454

Muller (2003) Medicinal chemistry of adenosine A₃ receptor ligands. Curr.Top.Med.Chem. 3 445 PMID: 12570761

Ozola et al (2003) 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at human A₃ adenosine receptors. Bioorg.Med.Chem. 11 347 PMID: 12517430

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关键词: PSB 11 hydrochloride, PSB 11 hydrochloride supplier, Potent, selective, human, A3, receptor, antagonists, inverse, agonists, Receptors, adenosines, PSB11, hydrochloride, Adenosine, 2012, Tocris Bioscience

篇 PSB 11 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 PSB 11 hydrochloride 的引用文献。