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Submit ReviewPSB 1114
说明： Potent, selective P2Y2 agonist
化学名： 4-Thiouridine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt
纯度： ≥98% (HPLC)
生物活性 for PSB 1114
PSB 1114 is a potent, selective P2Y2 agonist (EC50 = 0.134 μM). Displays >60-fold selectivity versus P2Y4 and P2Y6 receptors.
技术数据 for PSB 1114
| 分子量 | 622.14 |
| 公式 | C10H11F2N2Na4O13P3S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1657025-60-9 |
| PubChem ID | 90488930 |
| InChI Key | KATPYMNMKKBLAH-GENVZAMMSA-J |
| Smiles | [Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)C(O[C@@H]1COP([O-])(=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O)N1C=CC(=S)NC1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PSB 1114
| 溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
产品说明书 for PSB 1114
参考文献 for PSB 1114
参考文献是支持产品生物活性的出版物。
El-Tayeb et al (2011) Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J.Med.Chem. 54 2878 PMID: 21417463
If you know of a relevant reference for PSB 1114, please let us know.
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关键词: PSB 1114, PSB 1114 supplier, PSB1114, P2Y2, receptors, agonist, purinergic, P2Y, 2, agonists, purinoceptors, Purinergic, Receptors, 4333, Tocris Bioscience
2 篇 PSB 1114 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PSB 1114 的部分引用包括：
Roshanravan and Dryer (2014) ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species. Neuropsychopharmacology 306 F1088 PMID: 24553432
Ana C et al (2020) Vascular control of the CO2/H+-dependent drive to breathe. Elife 9 PMID: 32924935
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.