PSB 1115

Cat. No. 2009 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective human A_2B antagonist; water-soluble

化学名： 4-(2,3,6,7-Tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonic acid

纯度： ≥98% (HPLC)

引用文献 (10)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PSB 1115

PSB 1115 is a highly selective, water-soluble, human A_2B adenosine receptor antagonist. K_i values are 53.4, > 10000 and > 10000 nM at human A_2B, A₁ and A₃ receptors respectively. Also selective versus rat A₁ and A_2A receptors (K_i values are 2200 and 24000 nM respectively). Produces potent analgesic effects in vivo.

化合物库 for PSB 1115

PSB 1115 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PSB 1115

分子量	350.35
公式	C₁₄H₁₄N₄O₅S
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	152529-79-8
PubChem ID	5311479
InChI Key	UYDRRQPGDSIMNU-UHFFFAOYSA-N
Smiles	O=C(NC2=C1NC(C3=CC=C(S(=O)(O)=O)C=C3)=N2)N(CCC)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PSB 1115

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	38.84	100
	water	7.77	20 温和加热

制备储备液 for PSB 1115

以下数据基于产品分子量 350.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.27 mL	28.54 mL
5 mM	0.57 mL	2.85 mL	5.71 mL
10 mM	0.29 mL	1.43 mL	2.85 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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产品说明书 for PSB 1115

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PSB 1115

参考文献是支持产品生物活性的出版物。

Muller et al (1998) 8-(Sulfostyryl)xanthines: water-soluble A_2A-selective adenosine receptor antagonists. Bioorg.Med.Chem. 6 707 PMID: 9681137

Hayallah et al (2002) 1,8-Disubstituted xanthine derivatives: synthesis of potent A_2B-selective adenosine receptor antagonists. J.Med.Chem. 45 1500 PMID: 11906291

Abo-Salem et al (2004) Antinociceptive effects of novel A_2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther. 308 358 PMID: 14563788

Yan and Muller (2004) Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. J.Med.Chem. 47 1031 PMID: 14761205

If you know of a relevant reference for PSB 1115, please let us know.

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关键词: PSB 1115, PSB 1115 supplier, Selective, human, A2B, receptors, antagonists, water-soluble, adenosines, PSB1115, Adenosine, Receptors, 2009, Tocris Bioscience