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PSB 36

Cat. No. 2019 6 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2019 has been discontinued.

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说明： Potent and selective A1 antagonist
化学名： 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione
纯度： ≥99% (HPLC)
说明书
引用文献 (6)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for PSB 36

PSB 36 is a potent and selective A1 adenosine receptor antagonist. PSB 36 displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B, rA2A, rA3 and hA3 receptors respectively. PSB 36 demonstrates greater selectivity than DPCPX (Cat. No. 0439). PSB 36 reduces atrial fibrillation in rat isolated beating heart preparations.

技术数据 for PSB 36

分子量 386.49
公式 C21H30N4O3
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 524944-72-7
PubChem ID 11689583
InChI Key CIBIXJYFYPFMTN-UHFFFAOYSA-N
Smiles CCCCN1C(=O)N(CCCO)C2=C(NC(=N2)C23CC4CC2CC(C3)C4)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PSB 36

参考文献是支持产品生物活性的出版物。

Abo-Salem et al (2004) Antinociceptive effects of novel A2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther 308 358 PMID: 14563788

Weyler et al (2006) Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones. Chem.Med.Chem. 1 891

Soattin et al (2020) Inhibition of adenosine pathway alters atrial electrophysiology and prevents atrial fibrillation. Front Physiol. 11 493 PMID: 32595514

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关键词: PSB 36, PSB 36 supplier, Potent, selective, A1, antagonists, Receptors, adenosines, PSB36, Adenosine, 2019, Tocris Bioscience

6 篇 PSB 36 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PSB 36 的部分引用包括：

Soattin et al (2020) Inhibition of adenosine pathway alters atrial electrophysiology and prevents atrial fibrillation. Front Physiol. 11 493 PMID: 32595514

Ziemlinska et al (2014) Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PLoS One 9 e88833 PMID: 24551172

Cheng et al (2017) Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure 25 1275 PMID: 28712806

Arnal et al (2013) Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups. Respir Physiol Neurobiol 186 73 PMID: 23318703

Carlström et al (2010) Adenosine A(2) receptors modulate tubuloglomerular feedback. Am J Physiol Renal Physiol 299 F412 PMID: 20519378

Guerreiro et al (2008) Paraxanthine, the primary metabolite of caffeine, provides protection against DArgic cell death via stimulation of ryanodine receptor channels. Mol Pharmacol 74 980 PMID: 18621927

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