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Submit ReviewPSB 603
说明： Highly selective A2B antagonist
化学名： 8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
纯度： ≥98% (HPLC)
生物活性 for PSB 603
PSB 603 is an adenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively).
化合物库 for PSB 603
PSB 603 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for PSB 603
| 分子量 | 529.01 |
| 公式 | C24H25ClN6O4S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1092351-10-4 |
| PubChem ID | 44185871 |
| InChI Key | OVHCTHHFOHMNFV-UHFFFAOYSA-N |
| Smiles | O=C(NC2=C1NC(C3=CC=C(S(N4CCN(C5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PSB 603
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 26.45 | 50 |
制备储备液 for PSB 603
以下数据基于产品分子量 529.01。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.78 mL | 18.9 mL | 37.81 mL |
| 2.5 mM | 0.76 mL | 3.78 mL | 7.56 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 25 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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产品说明书 for PSB 603
参考文献 for PSB 603
参考文献是支持产品生物活性的出版物。
Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717
If you know of a relevant reference for PSB 603, please let us know.
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关键词: PSB 603, PSB 603 supplier, selective, A2B, antagonists, Receptors, adenosines, PSB603, Adenosine, 3198, Tocris Bioscience
6 篇 PSB 603 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PSB 603 的部分引用包括：
Kang et al (2016) Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts. Sci Adv 2 e1600691 PMID: 27602403
Ham et al (2010) Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. Proc Natl Acad Sci U S A 335 607 PMID: 20805305
Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Oncogene 14 201 PMID: 26597723
Long et al (2015) p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. J Pharmacol Exp Ther 34 5152 PMID: 25659586
Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661 PMID: 26030448
Rao et al (2015) Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices. Front Bioeng Biotechnol 3 185 PMID: 26618155
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