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说明： PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
化学名： 5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3',2':3,4]diazepino[6,7,1-hi]indole hydrochloride
纯度： ≥98% (HPLC)
生物活性 for PSEM 308 hydrochloride
PSEM 308 hydrochloride is a PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels.
Recommended concentration for use in mice is 5 mg/kg or lower.
Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
许可信息
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.
技术数据 for PSEM 308 hydrochloride
| 分子量 | 303.83 |
| 公式 | C17H21N3.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 134812838 |
| InChI Key | VMTPPUMVLGEJNP-UHFFFAOYSA-N |
| Smiles | CC1CC2=CC=CC3=C2N1N=C4C(C3)[N@@]5CC[C@H]4CC5.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PSEM 308 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 6.08 | 20 | |
| ethanol | 6.08 | 20 温和加热 |
制备储备液 for PSEM 308 hydrochloride
以下数据基于产品分子量 303.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 16.46 mL | 82.28 mL | 164.57 mL |
| 1 mM | 3.29 mL | 16.46 mL | 32.91 mL |
| 2 mM | 1.65 mL | 8.23 mL | 16.46 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.29 mL |
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产品说明书 for PSEM 308 hydrochloride
参考文献 for PSEM 308 hydrochloride
参考文献是支持产品生物活性的出版物。
Lovett-Barron et al (2012) Regulation of neuronal input transformations by tunable dendritic inhibition. Nat.Neurosci. 15 423 PMID: 22246433
Satoh et al (2016) Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons. Neuron 89 1046 PMID: 26924434
Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Nature 488 172 PMID: 22801496
Hirschberg et al (2017) Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 6 e29808 PMID: 29027903
If you know of a relevant reference for PSEM 308 hydrochloride, please let us know.
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.