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说明： PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
化学名： N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate
纯度： ≥98% (HPLC)
生物活性 for PSEM 89S
PSEM 89S is a PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant.
Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
许可信息
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.
技术数据 for PSEM 89S
| 分子量 | 404.38 |
| 公式 | C16H22N2O3.CF3CO2H |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1336913-03-1 |
| PubChem ID | 134812840 |
| InChI Key | GLKCNNXBIUCCJJ-PFEQFJNWSA-N |
| Smiles | OC(C(F)(F)F)=O.O=C(N[C@@H]1CN2CCC1CC2)C(C=C3OC)=C(C=C3)OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PSEM 89S
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 40.44 | 100 | |
| water | 40.44 | 100 |
制备储备液 for PSEM 89S
以下数据基于产品分子量 404.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.36 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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产品说明书 for PSEM 89S
参考文献 for PSEM 89S
参考文献是支持产品生物活性的出版物。
Magnus et al (2011) Chemical and genetic engineering of selective ion channel-ligand interactions. Science 333 1292 PMID: 21885782
Cerritelli et al (2016) Activation of brainstem pro-opiomelanocortin neurons produces opioidergic analgesia, bradycardia and bradypnoea. PLoS One 11 e0153187 PMID: 27077912
If you know of a relevant reference for PSEM 89S, please let us know.
关键词: PSEM 89S, PSEM 89S supplier, PSEM89S, PSAM, L141F-GlyR, chimeric, channel, pharmacologically, selective, actuator, module, agonists, agonism, activates, activators, L141F,Y115F-5HT3, 5-HT3, effector, modules, chemogenetics, Glycine, Receptors, PSEMs, 6426, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.