PU H71

Discontinued Product

3104 has been discontinued.

View all Hsp90 products.
说明: Potent Hsp90 inhibitor
化学名: 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
纯度: ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (2)

生物活性 for PU H71

PU H71 is a potent inhibitor of heat shock protein 90 (Hsp90) (IC50 = 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC50 values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells respectively). Shown to inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.

技术数据 for PU H71

分子量 512.37
公式 C18H21IN6O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 873436-91-0
PubChem ID 9549213
InChI Key SUPVGFZUWFMATN-UHFFFAOYSA-N
Smiles IC1=CC4=C(OCO4)C=C1SC3=NC2=C(N)N=CN=C2N3CCCNC(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PU H71

分析证书/产品说明书
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参考文献 for PU H71

参考文献是支持产品生物活性的出版物。

He et al (2006) Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. J.Med.Chem. 49 381 PMID: 16392823

Chan et al (2008) Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects. Cancer Res. 68 216 PMID: 18172314

Caldas-Lopes et al (2009) Hsp90 inhibitor, PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc.Natl.Acad.Sci.USA 106 8368 PMID: 19416831

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关键词: PU H71, PU H71 supplier, PUH71, heat, shock, proteins, hsp90, inhibitors, inhibits, potent, Hsp90, 3104, Tocris Bioscience

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