Purvalanol A

Cat. No. 1580 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

别名： NG 60

化学名： (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

纯度： ≥98% (HPLC)

引用文献 (8)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Purvalanol A

Purvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 4, 4 - 70, 75 - 240 and 100 nM for cdk1, cdk2, cdk5 and cdk 7, respectively). Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

许可信息

Sold under license from the Regents of the University of California

化合物库 for Purvalanol A

Purvalanol A is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Purvalanol A

分子量	388.9
公式	C₁₉H₂₅ClN₆O
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	212844-53-6
PubChem ID	456214
InChI Key	PMXCMJLOPOFPBT-HNNXBMFYSA-N
Smiles	ClC1=CC=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Purvalanol A

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	19.45	50
	DMSO	38.89	100

制备储备液 for Purvalanol A

以下数据基于产品分子量 388.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.86 mL	25.71 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.29 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Purvalanol A

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Purvalanol A

参考文献是支持产品生物活性的出版物。

Bain et al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199 PMID: 12534346

Gray et al (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281 533 PMID: 9677190

Gray et al (1999) ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 6 859 PMID: 10495356

Villerbu et al (2002) Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int.J.Cancer 97 761 PMID: 11857351

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for Purvalanol A, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Non-selective CDK Inhibitors

关键词: Purvalanol A, Purvalanol A supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdk, PurvalanolA, NG60, NG, 60, Kinase, Non-selective, CDKs, 1580, Tocris Bioscience