主页 / 药理学 / Enzymes / Kinases / Cyclin-Dependent Kinases (CDKs) / Non-selective CDKs / Non-selective CDK Inhibitors / Purvalanol B

Purvalanol B

Cat. No. 1581 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
别名： NG 95
化学名： (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Purvalanol B

Purvalanol B is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 nM for cdk1 and cdk5, and 6 - 9 nM for cdk2, depending on binding partner). Purvalanol B is selective over a range of other protein kinases (IC50 >10,000 nM). Purvalanol B shows antiproliferative properties, mediated by ERK1 and ERK2. Purvalanol B induces autophagy in cellular models and induces apoptosis in cancer cells, the apoptotic effects can be increased by combining with Rapamycin (Cat. No. 1292).

许可信息

Sold under license from the Regents of the University of California

化合物库 for Purvalanol B

Purvalanol B is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Purvalanol B

分子量 432.91
公式 C20H25ClN6O3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 212844-54-7
PubChem ID 448991
InChI Key ZKDXRFMOHZVXSG-HNNXBMFYSA-N
Smiles CC(C)[C@H](CO)NC1=NC(NC2=CC(Cl)=C(C=C2)C(O)=O)=C2N=CN(C(C)C)C2=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Purvalanol B

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. NaOH 43.29 100 温和加热
DMSO 43.29 100

制备储备液 for Purvalanol B

以下数据基于产品分子量 432.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.55 mL 23.1 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for Purvalanol B

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Purvalanol B

参考文献是支持产品生物活性的出版物。

Gray et al (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281 533 PMID: 9677190

Gray et al (1999) ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 6 859 PMID: 10495356

Knockaert et al (2002) p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene 21 6413 PMID: 12226745

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

Ozfiliz-Kilbas et al (2018) Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells. Mol.Biol.Rep. 45 815 PMID: 29978381

If you know of a relevant reference for Purvalanol B, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Non-selective CDK Inhibitors

关键词: Purvalanol B, Purvalanol B supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdk, PurvalanolB, NG95, potent, cdk1, cdk2, cdk5, selective, antiproliferative, apoptosis, autophagy, NG, 95, Kinase, Non-selective, CDKs, 1581, Tocris Bioscience

3 篇 Purvalanol B 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Purvalanol B 的部分引用包括：

Schreiber et al (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9 1047 PMID: 20071362

Wissing et al (2007) Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. J Pharmacol Exp Ther 6 537 PMID: 17192257

Ma et al (2019) Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation. Nat Commun 10 296 PMID: 30655532

您是否知道使用了 Tocris Purvalanol B 的优秀论文？ 请告知我们.

Purvalanol B 的评论

目前没有该产品的评论。 Be the first to review Purvalanol B and earn rewards!

Have you used Purvalanol B?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review