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Submit Review[Pyr1]-Apelin-13
说明： Potent peptide apelin agonist
别名： [pGlu1]-Apelin-13
纯度： ≥95% (HPLC)
生物活性 for [Pyr1]-Apelin-13
[Pyr1]-Apelin-13 is a highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.
技术数据 for [Pyr1]-Apelin-13
| 分子量 | 1533.81 |
| 公式 | C69H108N22O16S |
| 序列 |
XRPRLSHKGPMPF (Modifications: X = Glp) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 217082-60-5 |
| PubChem ID | 25085173 |
| InChI Key | GGMAXEWLXWJGSF-PEWBXTNBSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for [Pyr1]-Apelin-13
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for [Pyr1]-Apelin-13
参考文献 for [Pyr1]-Apelin-13
参考文献是支持产品生物活性的出版物。
Katugampola et al (2001) [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 132 1255 PMID: 11250876
Kagiyama et al (2005) Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 125 55 PMID: 15582714
Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471
Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198 PMID: 15907343
If you know of a relevant reference for [Pyr1]-Apelin-13, please let us know.
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关键词: [Pyr1]-Apelin-13, [Pyr1]-Apelin-13 supplier, Potent, peptide, agonists, APJ, Receptors, Apelin, adipokines, [pGlu1]-Apelin-13, 2420, Tocris Bioscience
2 篇 [Pyr1]-Apelin-13 的引用文献
引用文献是使用了 Tocris 产品的出版物。 [Pyr1]-Apelin-13 的部分引用包括：
Li (2018) Apelin modulates murine gastric vagal afferent mechanosensitivity. Physiol Behav 194 466 PMID: 29964068
Hall et al (2017) Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth. Cancer Lett 386 179 PMID: 27894959
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