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说明： Enhances survival of human ESCs following enzymatic dissociation
化学名： N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide
纯度： ≥98% (HPLC)
生物活性 for Pyrintegrin
Pyrintegrin enhances survival of human embryonic stem cells (hESCs) following enzymatic dissociation. Thought to enhance cell-ECM adhesion and activate integrin signaling. Pyrintegrin increases adhesion of hESCs to matrigel- and laminin-coated plates, but not to gelatin-coated plates. Also podocyte-protective agent and prevents LPS-induced proteinuria in mice.
化合物库 for Pyrintegrin
Pyrintegrin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Pyrintegrin
| 分子量 | 451.54 |
| 公式 | C23H25N5O3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1228445-38-2 |
| PubChem ID | 46223724 |
| InChI Key | QRJTZIJWDLJKQO-UHFFFAOYSA-N |
| Smiles | OC(C=C3)=CC2=C3N(CCC2)C1=NC(NC4=CC=C(S(NCC5CC5)(=O)=O)C=C4)=NC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Pyrintegrin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 45.15 | 100 |
制备储备液 for Pyrintegrin
以下数据基于产品分子量 451.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.07 mL | 22.15 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.43 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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产品说明书 for Pyrintegrin
参考文献 for Pyrintegrin
参考文献是支持产品生物活性的出版物。
Xu et al (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc.Natl.Acad.Sci.USA 107 8129 PMID: 20406903
Lee et al (2015) A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules. J.Am.Soc.Nephrol 26 2741 PMID: 25858967
If you know of a relevant reference for Pyrintegrin, please let us know.
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关键词: Pyrintegrin, Pyrintegrin supplier, human, embryonic, stem, cells, hESCs, survival, culture, podocytes, renal, kidney, protective, Stem, Cell, Proliferation, 4978, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.