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QS 11

Cat. No. 3324 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
化学名： (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for QS 11

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.

化合物库 for QS 11

QS 11 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for QS 11

分子量 567.68
公式 C36H33N5O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 944328-88-5
PubChem ID 42623900
InChI Key DOKZLKDGUQWMSX-HKBQPEDESA-N
Smiles OC[C@H](CC6=CC=CC=C6)NC1=C2C(N(CC3=CC=C(C7=CC=CC=C7)C=C3)C=N2)=NC(OC4=CC=C(CCC5)C5=C4)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for QS 11

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 56.77 100
ethanol 56.77 100

制备储备液 for QS 11

以下数据基于产品分子量 567.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.81 mL 17.62 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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产品说明书 for QS 11

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for QS 11

参考文献是支持产品生物活性的出版物。

Zhang et al (2007) Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc.Natl.Acad.Sci.USA 104 7444 PMID: 17460038

Emre et al (2007) A chemical approach to stem cell biology Curr.Opin.Chem.Biol. 11 252 PMID: 17493865

If you know of a relevant reference for QS 11, please let us know.

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关键词: QS 11, QS 11 supplier, QS11, ARFGAP1, inhibitor, inhibits, modulator, Wnt, signaling, signalling, ADP-ribosylation, factor, 1, inhibitors, Other, Signaling, Stem, Cell, Arf, 3324, Tocris Bioscience

2 篇 QS 11 的引用文献

引用文献是使用了 Tocris 产品的出版物。 QS 11 的部分引用包括：

Gowda et al (2018) Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression. Mol Cell Biol 38 PMID: 29463646

Wu, J et al (2016) Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles Scientific Reports 6 29418 PMID: 27435629

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