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Quin C1

Cat. No. 5583 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective FPR2 agonist
化学名： 4-Butoxy-N-[1,4-dihydro-2-(4-methoxyphenyl)-4-oxo-3(2H)-quinazolinyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Quin C1

Quin C1 is a potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.

技术数据 for Quin C1

分子量 445.51
公式 C26H27N3O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 786706-21-6
PubChem ID 11751175
InChI Key XORVAHQXRDLSFT-UHFFFAOYSA-N
Smiles O=C1N(NC(C2=CC=C(OCCCC)C=C2)=O)C(C3=CC=C(OC)C=C3)NC4=CC=CC=C41

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Quin C1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.55 100

制备储备液 for Quin C1

以下数据基于产品分子量 445.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.22 mL 22.45 mL
5 mM 0.45 mL 2.24 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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参考文献 for Quin C1

参考文献是支持产品生物活性的出版物。

Zhou et al (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 72 976 PMID: 17652444

Corminboeuf et al (2014) FPR2/ALXR agonists and the resolution of inflammation. J.Med.Chem. 58 537 PMID: 25365541

If you know of a relevant reference for Quin C1, please let us know.

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关键词: Quin C1, Quin C1 supplier, QuinC1, potent, selective, agonists, agonism, FPR2, FPRL1, formyl, peptide, receptor-like, 1, inflammation, anti-inflammatory, Formyl, Peptide, Receptors, 5583, Tocris Bioscience

1 篇 Quin C1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Quin C1 的部分引用包括：

Ma et al (2015) Agonist and antagonist effects of aripipr. on D2-like receptors controlling rat brain DA synthesis depend on the DArgic tone. Int J Neuropsychopharmacol 18 PMID: 25522390

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