QX 314 bromide

Name: QX 314 bromide
Brand: Tocris Bioscience
SKU: 1014
Rating: 5 (1 reviews)

Cat. No. 1014 32 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Na⁺ channel blocker

化学名： N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide

纯度： ≥99% (HPLC)

说明书

引用文献 (32)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for QX 314 bromide

QX 314 bromide is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na⁺ channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.

技术数据 for QX 314 bromide

分子量	343.31
公式	C₁₆H₂₇N₂OBr
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	24003-58-5
PubChem ID	9884487
InChI Key	DLHMKHREUTXMCH-UHFFFAOYSA-N
Smiles	[Br-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for QX 314 bromide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water		100

制备储备液 for QX 314 bromide

以下数据基于产品分子量 343.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.91 mL	14.56 mL	29.13 mL
5 mM	0.58 mL	2.91 mL	5.83 mL
10 mM	0.29 mL	1.46 mL	2.91 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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产品说明书 for QX 314 bromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for QX 314 bromide

参考文献是支持产品生物活性的出版物。

Alreja and Aghajanian (1994) QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain.Res. 639 320 PMID: 8205485

Stichartz et al (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 62 37 PMID: 4541340

Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 73 911 PMID: 7760149

Talbot and Sayer (1996) Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J.Neurophysiol. 76 2120 PMID: 8890325

If you know of a relevant reference for QX 314 bromide, please let us know.

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关键词: QX 314 bromide, QX 314 bromide supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX314, bromide, Voltage-gated, 1014, Tocris Bioscience

32 篇 QX 314 bromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 QX 314 bromide 的部分引用包括：

Acuña et al (2016) Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain. J Clin Invest 126 2547 PMID: 27270175

Puranam et al (2015) Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus. Korean J Physiol Pharmacol 35 8866 PMID: 26063919

Ahn et al (2015) Characteristics of K(+) Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week. PLoS One 19 383 PMID: 26170743

Lench et al (2015) Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site. Toxins (Basel) 10 e0133548 PMID: 26193112

Egawa et al (2013) Optogenetic probing and manipulation of the calyx-type presynaptic terminal in the embryonic chick ciliary ganglion. PLoS One 8 e59179 PMID: 23555628

Wu et al (2013) Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses. J Neurosci 33 16158 PMID: 24107948

Li et al (2019) TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife 8 PMID: 31482844

Linnemann et al (2006) Transient change in GABA(A) receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration. Neuron 7 59 PMID: 16872511

Xu et al (2006) Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Mol Pain 2 29 PMID: 16948848

He and Bausch (2014) Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis. BMC Neurosci 77 379 PMID: 24184417

Baldelli et al (2007) Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses. J Neurosci 27 13520 PMID: 18057210

He et al (2013) Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition. J Neurosci 109 1535 PMID: 23255721

Zhang et al (2008) Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation. Exp Neurol 212 44 PMID: 18495119

Toyoda et al (2007) Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex. Mol Pain 3 36 PMID: 18053155

Gipson and Yeckel (2007) Coincident glutamatergic and cholinergic inputs transiently depress glutamate release at rat schaffer collateral synapses. J Neurophysiol 97 4108 PMID: 17303811

Sametsky et al (2015) Enhanced GABAA-Mediated Tonic Inhibition in Auditory Thalamus of Rats with Behavioral Evidence of Tinnitus. J Neurosci 35 9369 PMID: 26109660

Xue et al (2015) Structural elements that underlie Doc2β function during asynchronous synaptic transmission. Proc Natl Acad Sci U S A 112 E4316 PMID: 26195798

McGee et al (2015) Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci 35 16171 PMID: 26658868

Dale et al (2014) Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol 28 891 PMID: 25122043

Gaffaney et al (2014) Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission. Mol Biol Cell 25 481 PMID: 24356452

Hong et al (2008) Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice. J Neurosci 28 13003 PMID: 19036993

Purkey et al (2018) AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca²⁺-Permeable AMPA Receptors to Control LTP. Cell Rep 25 974 PMID: 30355502

Chuhma et al (2014) DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling. Proc Natl Acad Sci U S A 81 901 PMID: 24559678

Kuroyanagi et al (2009) Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission. J Neurophysiol 106 4912 PMID: 19258455

Chen and Chesler (2015) Autocrine boost of NMDAR current in hippocampal CA1 pyramidal neurons by a PMCA-dependent, perisynaptic, extracellular pH shift. J Neurosci 35 873 PMID: 25609607

Toyoda et al (2009) Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex. Mol Pain 5 46 PMID: 19664265

Sur et al (2003) N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-MthD.-aspartate receptor activity. Proc Natl Acad Sci U S A 100 13674 PMID: 14595031

He et al (2020) Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice Cell rep 33 PMID: 33147466

Lerner et al (2010) Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. J Neurosci 30 2160 PMID: 20147543

Zhang et al (2009) Tamox. mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model. Brain Res 1247 196 PMID: 18992727

Spoljaric et al (2019) KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice. Cell Rep 26 1073 PMID: 30699338

Ferrarese et al (2018) Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo. Cell Rep 24 3455 PMID: 30257207

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QX-314 bromide blocks action potentials propagation.

By Anonymous on 08/17/2019

分析类型： In Vitro

种属： Rat

细胞系/组织： Hippocampus

QX-314 was used to block voltage-gated sodium channels, i.e. prevent action potential propagation. The compound develops its effect in 1 microM concentration, in use-dependent mode. Figure: EPSC evoked by electrical stimulation in hippocampal pyramidal neuron at positive membrane potential (+40 mV); QX-314 is added to intracellular solution.