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Submit ReviewQX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.
分子量 | 298.85 |
公式 | C16H27N2OCl |
储存 | Store at RT |
纯度 | ≥99% (HPLC) |
CAS Number | 5369-03-9 |
PubChem ID | 21462 |
InChI Key | LLPPOMUAOGMYQI-UHFFFAOYSA-N |
Smiles | [Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 30 | 100 |
以下数据基于产品分子量 298.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.35 mL | 16.73 mL | 33.46 mL |
5 mM | 0.67 mL | 3.35 mL | 6.69 mL |
10 mM | 0.33 mL | 1.67 mL | 3.35 mL |
50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
参考文献是支持产品生物活性的出版物。
Stichartz et al (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 62 37 PMID: 4541340
Alreja and Aghajanian (1994) QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res. 639 320 PMID: 8205485
Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 72 911 PMID: 7760149
If you know of a relevant reference for QX 314 chloride, please let us know.
关键词: QX 314 chloride, QX 314 chloride supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX314, chloride, Voltage-gated, 2313, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 QX 314 chloride 的部分引用包括:
Dong et al (2018) CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell Rep 24 284 PMID: 29996090
Collins et al (2018) Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron 98 366 PMID: 29628187
Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. Mol Pain 9 115 PMID: 25918499
Cunningham et al (2014) hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell 15 559 PMID: 25517465
Arvin et al (2019) Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine. J Vis Exp 143 e58873 PMID: 30735191
Hull (2017) Measuring Feedforward Inhibition and Its Impact on Local Circuit Function. Cold Spring Harb Protoc 2017 PMID: 28461661
Wood et al (2009) Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. Front Cell Neurosci 29 12440 PMID: 19812320
Birdsong et al (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife 8 PMID: 31099753
Wang et al (2006) DArgic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. Neuron 50 443 PMID: 16675398
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QX-314 chloride was used to isolate membrane capacitance fluctuations due to release of neurotransmitter vesicles. Picture: fluctuation of a neuron membrane capacitance after electrical series stimulation of neural tissue; intracellular solution contains 5 mM QX-314.
In whole cell electrophysiology experiments, we include this in our internal solution to block voltage gated sodium channels. Typically, we use 5-30 mM. Blockade is use-dependent. Drug needs some time and activity to be more effective. Picture is of a putative evoked EPSC in a cell held at +40mV with Qx-314 in internal solution.