QX 314 chloride

Pricing Availability   Qty
说明: Na+ channel blocker
化学名: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
纯度: ≥99% (HPLC)
说明书
引用文献 (9)
评论 (3)

生物活性 for QX 314 chloride

QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.

技术数据 for QX 314 chloride

分子量 298.85
公式 C16H27N2OCl
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 5369-03-9
PubChem ID 21462
InChI Key LLPPOMUAOGMYQI-UHFFFAOYSA-N
Smiles [Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for QX 314 chloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 30 100

制备储备液 for QX 314 chloride

以下数据基于产品分子量 298.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.35 mL 16.73 mL 33.46 mL
5 mM 0.67 mL 3.35 mL 6.69 mL
10 mM 0.33 mL 1.67 mL 3.35 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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产品说明书 for QX 314 chloride

分析证书/产品说明书
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参考文献 for QX 314 chloride

参考文献是支持产品生物活性的出版物。

Stichartz et al (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 62 37 PMID: 4541340

Alreja and Aghajanian (1994) QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res. 639 320 PMID: 8205485

Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 72 911 PMID: 7760149


If you know of a relevant reference for QX 314 chloride, please let us know.

关键词: QX 314 chloride, QX 314 chloride supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX314, chloride, Voltage-gated, 2313, Tocris Bioscience

9 篇 QX 314 chloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 QX 314 chloride 的部分引用包括:

Dong et al (2018) CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell Rep 24 284 PMID: 29996090

Collins et al (2018) Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron 98 366 PMID: 29628187

Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. Mol Pain 9 115 PMID: 25918499

Cunningham et al (2014) hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice. Cell Stem Cell 15 559 PMID: 25517465


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Block of sodium channels in vitro.
By Sergiy Sylantyev on 12/10/2023
分析类型: In Vitro
种属: Mouse
细胞系/组织: Arcuate nucleus

QX-314 chloride was used to isolate membrane capacitance fluctuations due to release of neurotransmitter vesicles. Picture: fluctuation of a neuron membrane capacitance after electrical series stimulation of neural tissue; intracellular solution contains 5 mM QX-314.

PMID: 37827445
review image

Whole cell recordings with blocked action potentials.
By Anonymous on 05/08/2018
分析类型: Ex Vivo
种属: Mouse

In whole cell electrophysiology experiments, we include this in our internal solution to block voltage gated sodium channels. Typically, we use 5-30 mM. Blockade is use-dependent. Drug needs some time and activity to be more effective. Picture is of a putative evoked EPSC in a cell held at +40mV with Qx-314 in internal solution.

review image

QX314+capsaicin blocks c fiber activities.
By Jing Feng on 01/10/2018
分析类型: In Vivo
种属: Mouse

QX314 was used to block the activities of TRPV1-positive fibers in AEW-induced chronic itch model

QX314 should be injected with capsaicin.QX314: 200ug/mouseCapsaicin: 0.1%

review image