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Submit ReviewR 7050
说明： Inhibitor of TNF-α receptor 1 signaling
化学名： 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
纯度： ≥98% (HPLC)
生物活性 for R 7050
R 7050 is an inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.
技术数据 for R 7050
| 分子量 | 380.77 |
| 公式 | C16H8ClF3N4S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 303997-35-5 |
| PubChem ID | 1486608 |
| InChI Key | SUUMKHOVGVYGOP-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N=C(SC4=CC=CC=C4)C2=NN=C(C(F)(F)F)N23)C3=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for R 7050
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 7.62 | 20 |
制备储备液 for R 7050
以下数据基于产品分子量 380.77。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.13 mL | 65.66 mL | 131.31 mL |
| 1 mM | 2.63 mL | 13.13 mL | 26.26 mL |
| 2 mM | 1.31 mL | 6.57 mL | 13.13 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
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产品说明书 for R 7050
参考文献 for R 7050
参考文献是支持产品生物活性的出版物。
Gururaja et al (2007) A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem.Biol. 14 1105 PMID: 17961823
King et al (2013) TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neurosci.Lett. 542 92 PMID: 23499961
If you know of a relevant reference for R 7050, please let us know.
关键词: R 7050, R 7050 supplier, R7050, tumor, necrosis, TNFa, TNFalpha, TNFα, inhibitors, inhibits, signaling, cytokines, receptors, Cytokine, Receptors, 5432, Tocris Bioscience
3 篇 R 7050 的引用文献
引用文献是使用了 Tocris 产品的出版物。 R 7050 的部分引用包括：
Gonzalez-Juarbe et al (2017) Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. Cell Death Differ 24 917 PMID: 28387756
Vicente et al (2022) Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia. Int J Mol Sci 23 PMID: 36233065
Dominic et al (2020) Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three-Dimensional Bone Tissue Engineering. ACS Nano 14 10027-10044 PMID: 32658450
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R 7050 的评论
平均评分: 5 (Based on 1 Review.)
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R 7050 inhibits 15d-PGJ2 induced caspase activation.
By
Chintan Koyani on 10/13/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： HL-1 cardiomyocytes
HL-1 cells were incubated with R 7050 (30 μM) for 30 min prior to 15d-PGJ2 (15 μM) treatments for 4 h to follow markers of apoptosis. Pharmacological antagonism of TNF receptor inhibited 15d-PGJ2-induced caspase 3/8/9 activation (shown in Image).
