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Submit ReviewR 715
说明： Potent and selective B1 antagonist
纯度： ≥95% (HPLC)
生物活性 for R 715
R 715 is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
技术数据 for R 715
| 分子量 | 1140.35 |
| 公式 | C57H81N13O12 |
| 序列 |
KRPPGFSXI (Modifications: Lys-1 = N-terminal Ac, X = DβNal) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 185052-09-9 |
| PubChem ID | 5311397 |
| InChI Key | DOSXOGUJJBDRGQ-VUBDHFCFSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for R 715
| 溶解性 | Soluble to 5 mg/ml in water |
产品说明书 for R 715
参考文献 for R 715
参考文献是支持产品生物活性的出版物。
Gobeil et al (1996) Structure-activity studies of B1 receptor-related peptides. Hypertension. 28 833 PMID: 8901831
Quintao et al (2008) Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J.Neurosci. 28 2856 PMID: 18337416
Abdouh et al (2008) Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors. Br.J.Pharmacol. 154 136 PMID: 18311190
If you know of a relevant reference for R 715, please let us know.
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关键词: R 715, R 715 supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R715, 3407, Tocris Bioscience
6 篇 R 715 的引用文献
引用文献是使用了 Tocris 产品的出版物。 R 715 的部分引用包括：
Falsetta et al (2016) A role for bradykinin signaling in chronic vulvar pain. The Journal of Pain PMID: 27544818
Xu et al (2014) Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4. Am J Respir Cell Mol Biol 51 370 PMID: 24669857
Albert-Weissenberger et al (2012) Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation. EMBO Mol Med 32 1747 PMID: 22569191
Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. J Cereb Blood Flow Metab 9 229 PMID: 26124706
Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324
Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70 PMID: 24047499
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R 715 的评论
平均评分: 5 (Based on 1 Review.)
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works good.
By
Anonymous on 05/13/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： neurons
B1 receptor antagonist R715, 2 µM
treat 20 min
