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(R)-(-)-Apomorphine hydrochloride

Cat. No. 2073 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Dopamine agonist; non-subtype-selective
化学名： (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (R)-(-)-Apomorphine hydrochloride

(R)-(-)-Apomorphine hydrochloride is a prototypical dopamine agonist (pKi values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D1, D2L, D3, D4 and D5 receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo.

技术数据 for (R)-(-)-Apomorphine hydrochloride

分子量 303.79
公式 C17H17NO2.HCl
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 314-19-2
PubChem ID 9410
InChI Key SKYZYDSNJIOXRL-BTQNPOSSSA-N
Smiles OC1=C2C(C[C@]4([H])C3=C2C=CC=C3CCN4C)=CC=C1O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (R)-(-)-Apomorphine hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 13.37 50
DMSO 30.38 100

制备储备液 for (R)-(-)-Apomorphine hydrochloride

以下数据基于产品分子量 303.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.46 mL 32.92 mL
5 mM 0.66 mL 3.29 mL 6.58 mL
10 mM 0.33 mL 1.65 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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产品说明书 for (R)-(-)-Apomorphine hydrochloride

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for (R)-(-)-Apomorphine hydrochloride

参考文献是支持产品生物活性的出版物。

Liu et al (1996) Low doses of apomor. suppress operant motor performance in rats. Pharmacol.Biochem.Behav. 53 335 PMID: 8808141

Grunblatt et al (1999) Apomorphine protects against MPTP-induced neurotoxicity in mice. Mov.Disord. 14 612 PMID: 10435498

Millan et al (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J.Pharmacol.Exp.Ther. 303 791 PMID: 12388666

If you know of a relevant reference for (R)-(-)-Apomorphine hydrochloride, please let us know.

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关键词: (R)-(-)-Apomorphine hydrochloride, (R)-(-)-Apomorphine hydrochloride supplier, Dopamine, agonists, non-subtype-selective, D2, D3, D4, Non-Selective, Receptors, D1, D5, dopaminergic, Non-selective, and, 2073, Tocris Bioscience

1 篇 (R)-(-)-Apomorphine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (R)-(-)-Apomorphine hydrochloride 的部分引用包括：

Huang (2018) DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice. Invest Ophthalmol Vis Sci 59 2623 PMID: 29847669

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