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(R)-(+)-Bay K 8644

Cat. No. 1545 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644; also TMEM176B inhibitor
化学名： (4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (R)-(+)-Bay K 8644

(R)-(+)-Bay K 8644 is a L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546). Also TMEM176B inhibitor. Induces IL-1β secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers.

Racemate and (S)-(-)-Enantiomer also available.

化合物库 for (R)-(+)-Bay K 8644

(R)-(+)-Bay K 8644 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for (R)-(+)-Bay K 8644

分子量 356.3
公式 C16H15F3N2O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 98791-67-4
PubChem ID 6604881
InChI Key ZFLWDHHVRRZMEI-CYBMUJFWSA-N
Smiles O=C(OC)C1=C(C)NC(C)=C([N+]([O-])=O)[C@@H]1[C@]2=CC=CC=C2C(F)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (R)-(+)-Bay K 8644

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 35.63 100
DMSO 35.63 100

制备储备液 for (R)-(+)-Bay K 8644

以下数据基于产品分子量 356.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.07 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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产品说明书 for (R)-(+)-Bay K 8644

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for (R)-(+)-Bay K 8644

参考文献是支持产品生物活性的出版物。

Franckowiak et al (1985) The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels. Eur.J.Pharmacol. 114 223 PMID: 2412855

O'Neill and Bolger (1988) Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644. Brain Res.Bull. 21 865 PMID: 2465070

Ravens and Schopper (1990) Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch.Pharmacol. 341 232 PMID: 1692975

Shi et al (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell. 3 568 PMID: 18983970

Segovia et al (2019) Targeting TMEM176B enhances antitumor immunity and augments the efficacy of immune checkpoint blockers by unleashing inflammasome activation. Cancer Cell. 35 767 PMID: 31085177

If you know of a relevant reference for (R)-(+)-Bay K 8644, please let us know.

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1 篇 (R)-(+)-Bay K 8644 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (R)-(+)-Bay K 8644 的部分引用包括：

Sidaway and Teramoto (2014) L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle. PLoS One 9 e93803 PMID: 24699670

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Test of VGCCs input into 5HT-1B effect on transmembrane current.
By Sergiy Sylantyev on 12/10/2023
分析类型： In Vitro
种属： Mouse
细胞系/组织： Arcuate nucleus

R-(+)-Bay-K (5 μM) was used as a part of a mixture (also containing 1 μM omega -Conotoxin GVIA and 1 μM omega -Agatoxin TK) which blocks voltage-gated calcium channels in a living neuron membrane. Left: the effect of activation of 5HT-1B and AMPA receptors on transmembrane current evoked upon membrane depolarization. Blue trace: control; red trace: 5HT-1B and AMPA receptors activation. Right: block of VGCCs results in 100% suppression of transmembrane current.

PMID: 37827445
review image