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Submit Review(R)-CPP
说明： Potent NMDA antagonist; more active enantiomer of (RS)-CPP
化学名： 3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
生物活性 for (R)-CPP
(R)-CPP is a highly potent NMDA antagonist; more active isomer. Shows some selectivity for GluN2A (formally NR2A) containing receptors (Ki values are 0.041, 0.27, 0.63 and 1.99 μM for inhibition of GluN2A-, GluN2B-, GluN2C- and GluN2D-containing recombinant NMDA receptors respectively).
Racemate also available.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for (R)-CPP
| 分子量 | 252.21 |
| 公式 | C8H17N2O5P |
| 储存 | Desiccate at RT |
| CAS Number | 126453-07-4 |
| PubChem ID | 6603754 |
| InChI Key | CUVGUPIVTLGRGI-SSDOTTSWSA-N |
| Smiles | [H][C@@]1([C@](O)=O)NCCN(CCCP(O)(O)=O)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (R)-CPP
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 25.22 | 100 |
制备储备液 for (R)-CPP
以下数据基于产品分子量 252.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.96 mL | 19.82 mL | 39.65 mL |
| 5 mM | 0.79 mL | 3.96 mL | 7.93 mL |
| 10 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.79 mL |
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产品说明书 for (R)-CPP
参考文献 for (R)-CPP
参考文献是支持产品生物活性的出版物。
Feng et al (2004) Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid. Br.J.Pharmacol. 141 508 PMID: 14718249
Aebischer et al (1989) Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene). Helv.Chim.Acta 72 1043
If you know of a relevant reference for (R)-CPP, please let us know.
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关键词: (R)-CPP, (R)-CPP supplier, Potent, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0247, Tocris Bioscience
15 篇 (R)-CPP 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (R)-CPP 的部分引用包括：
Vigot et al (2006) Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 50 589 PMID: 16701209
Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155 PMID: 21544206
Zhang et al (2018) Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell 174 1450 PMID: 30100184
Wood et al (2009) Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. Int J Neuropsychopharmacol 29 12440 PMID: 19812320
Mao et al Characterization and subcellular targeting of GCaMP-type genetically-encoded calcium indicators. Nat Commun 3 e1796 PMID: 18350138
Throesch et al (2024) Functional sensory circuits built from neurons of two species. Cell 187 2143 PMID: 38670072
Stephany et al (2014) Plasticity of binocularity and visual acuity are differentially limited by nogo receptor. PLoS One 34 11631 PMID: 25164659
Pan et al (2016) Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control. J Clin Invest 126 4516 PMID: 27797341
Tsutsui-Kimura et al (2015) Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. J Neurosci 18 PMID: 25522418
Chaffiol et al (2017) A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina. Mol Ther 25 2546 PMID: 28807567
Collins et al (2018) Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron 98 366 PMID: 29628187
Fan et al (2018) All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods 15 823 PMID: 30275587
Chang and Higley (2018) Potassium channels contribute to activity-dependent regulation of dendritic inhibition. Physiol Rep 6 e13747 PMID: 29939492
Maeder et al (2018) The THO Complex Coordinates Transcripts for Synapse Development and DA Neuron Survival. Cell 174 1436 PMID: 30146163
Sancho and Bloodgood (2018) Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex. Cell Rep 24 2075 PMID: 30134169
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CPP action on human neutrophils.
By
Anonymous on 07/13/2023
分析类型： In Vitro
种属： Human
细胞系/组织： Blood
(R)-CPP was used to quantify the input of Ca2+ flow through NMDA receptors into Ca2+ concentration fluctuations in human neutrophils. Figure: impact of (R)-CPP on Ca2+ - induced fluorescence in cultured neutrophils (+CPP bar).
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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