(R)-(+)-Etomoxir sodium salt

Name: ( R )-(+)-Etomoxir sodium salt
Brand: Tocris Bioscience
SKU: 4539
Rating: 5 (3 reviews)

Cat. No. 4539 16 篇引用文献 3 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Carnitine palmitoyltransferase I (CPT1) inhibitor

化学名： (R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt

纯度： ≥98% (HPLC)

说明书

引用文献 (16)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (R)-(+)-Etomoxir sodium salt

(R)-(+)-Etomoxir sodium salt is an inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

技术数据 for (R)-(+)-Etomoxir sodium salt

分子量	320.74
公式	C₁₅H₁₈ClNaO₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	828934-41-4
PubChem ID	57345784
InChI Key	RPACBEVZENYWOL-XFULWGLBSA-M
Smiles	[Na+].[O-]C(=O)[C@@]1(CCCCCCOC2=CC=C(Cl)C=C2)CO1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (R)-(+)-Etomoxir sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	6.41	20
	DMSO	6.41	20 温和加热

制备储备液 for (R)-(+)-Etomoxir sodium salt

以下数据基于产品分子量 320.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	15.59 mL	77.94 mL	155.89 mL
1 mM	3.12 mL	15.59 mL	31.18 mL
2 mM	1.56 mL	7.79 mL	15.59 mL
10 mM	0.31 mL	1.56 mL	3.12 mL

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产品说明书 for (R)-(+)-Etomoxir sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (R)-(+)-Etomoxir sodium salt

参考文献是支持产品生物活性的出版物。

Xu et al (2003) Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J.Lipid Res. 44 415 PMID: 12576524

Agius et al (1991) Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem.Pharmacol. 42 1717 PMID: 1930298

Rupp et al (1992) Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J. 6 2349 PMID: 1531968

If you know of a relevant reference for (R)-(+)-Etomoxir sodium salt, please let us know.

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关键词: (R)-(+)-Etomoxir sodium salt, (R)-(+)-Etomoxir sodium salt supplier, carnitine, o-palmitoyltransferase, acyltransferases, I, CPT1, inhibitors, inhibits, Other, Transferases, 4539, Tocris Bioscience

16 篇 (R)-(+)-Etomoxir sodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (R)-(+)-Etomoxir sodium salt 的部分引用包括：

Roberta et al (2021) Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes. J Vis Exp PMID: 34570107

Robert S et al (2021) α1-Adrenergic receptors increase glucose oxidation under normal and ischemic conditions in adult mouse cardiomyocytes. J Recept Signal Transduct Res 41 138-144 PMID: 32757689

Santosh et al (2021) The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. Cell Rep 34 108869 PMID: 33730581

Navdeep S et al (2021) Elevated CO2 Levels Delay Skeletal Muscle Repair by Increasing Fatty Acid Oxidation. Front Physiol 11 630910 PMID: 33551852

Jonas Thue et al (2021) Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis. Cell 184 3502-3518.e33 PMID: 34048700

Eduards et al (2021) Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism. Int J Mol Sci 22 PMID: 34208786

Scott I et al (2021) β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME. Cell Rep 37 109883 PMID: 34706232

Nancy et al (2015) Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. Neuro Oncol 17 1599-608 PMID: 26116612

Matthew D et al (2017) Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. Cell Metab 26 884-896.e5 PMID: 29107506

Janos et al (2016) Inhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cells. Eur J Pharmacol 780 202-8 PMID: 27041646

Dallas R et al (2016) Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells. J Cell Physiol 231 1804-13 PMID: 26661480

Elizabeth A et al (2022) Isolation of human and mouse myeloid-derived suppressor cells for metabolic analysis. STAR Protoc 3 101389 PMID: 35600927

Hamida et al (2019) Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells. Immunity 51 169-184.e5 PMID: 31231035

Joel D et al (2020) Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis. MBio 11 PMID: 32636249

Ryan M et al (2020) Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development. Cell Rep 30 2889-2899.e6 PMID: 32130894

Carine et al (2020) TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. Nat Commun 11 454 PMID: 31974393

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(R)-(+)-Etomoxir sodium salt 的评论

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Very effective for CPT-1 inhibiton.

By Anonymous on 03/27/2020

分析类型： In Vitro

种属： Human

细胞系/组织： MCF7

MCF7 cells were pretreated with or without 25, 50 μmol/L Etomoxir for 24 h.

Efficiently blocks FA catabolism in cell culture.

By Anonymous on 01/27/2020

分析类型： In Vitro

种属： Human

细胞系/组织： 293T

Product was diluted to 20 uM in tissue culture and various cancer cells were treated for 18-30 h at this concentration. Enzyme activity was measured by flow cytometry after. Results were strongly replicable.

Etomoxir shows good solubility profile when diluted from 20 mM stock in DMSO. Does not cause cell death across cell lines at 20 uM.

CPT1 inhibition.

By Anonymous on 01/04/2018

分析类型： Ex Vivo

种属： Mouse

细胞系/组织： acute brain slice

Exogenous application on acute brain slices

Pre-incubation of 15 minutes at 100 uM