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Submit Review(R)-(+)-HA-966
说明： NMDA partial agonist/antagonist; acts at glycine site
化学名： (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one
纯度： ≥98% (HPLC)
生物活性 for (R)-(+)-HA-966
(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier.
S-enantiomer also available.
许可信息
Sold with the permission of Merck Sharp and Dohme Ltd.
技术数据 for (R)-(+)-HA-966
| 分子量 | 116.12 |
| 公式 | C4H8N2O2 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 123931-04-4 |
| PubChem ID | 6603720 |
| InChI Key | HCKUBNLZMKAEIN-GSVOUGTGSA-N |
| Smiles | N[C@@H]1CCN(O)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (R)-(+)-HA-966
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 11.61 | 100 |
制备储备液 for (R)-(+)-HA-966
以下数据基于产品分子量 116.12。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 8.61 mL | 43.06 mL | 86.12 mL |
| 5 mM | 1.72 mL | 8.61 mL | 17.22 mL |
| 10 mM | 0.86 mL | 4.31 mL | 8.61 mL |
| 50 mM | 0.17 mL | 0.86 mL | 1.72 mL |
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产品说明书 for (R)-(+)-HA-966
参考文献 for (R)-(+)-HA-966
参考文献是支持产品生物活性的出版物。
Kemp and Priestley (1991) Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-MthD.-aspartate receptor agonist responses in cat cultured cortical neurons. Mol.Pharmacol. 39 666 PMID: 1674587
Pullan et al (1990) Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-MthD.-aspartate receptor complex. J.Neurochem. 55 1346 PMID: 1975835
Pullan et al (1991) Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966). Eur.J.Pharmacol. 208 25 PMID: 1834473
If you know of a relevant reference for (R)-(+)-HA-966, please let us know.
按产品操作查看相关产品
关键词: (R)-(+)-HA-966, (R)-(+)-HA-966 supplier, Partial, NMDA, agonists, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, merck, 0281, Tocris Bioscience
1 篇 (R)-(+)-HA-966 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (R)-(+)-HA-966 的部分引用包括：
Paquette et al (2008) σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias. Elife 19 111 PMID: 18281903
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