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Submit Review(R)-(+)-Methanandamide
说明： Potent and selective CB1 agonist
化学名： (R)-N-(2-Hydroxy-1-methylethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
纯度： ≥98% (HPLC)
生物活性 for (R)-(+)-Methanandamide
Stable anandamide analog that is a selective agonist for the CB1 receptor (Ki values are 20 and 815 nM for CB1 and CB2 receptors respectively). Also displays agonist activity at vanilloid receptors.
Water Soluble Emulsion also available.
技术数据 for (R)-(+)-Methanandamide
| 分子量 | 361.57 |
| 公式 | C23H39NO2 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 157182-49-5 |
| PubChem ID | 6321351 |
| InChI Key | SQKRUBZPTNJQEM-FQPARAGTSA-N |
| Smiles | O=C(N[C@H](C)CO)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (R)-(+)-Methanandamide
参考文献 for (R)-(+)-Methanandamide
参考文献是支持产品生物活性的出版物。
Abadji et al (1994) (R)-Methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J.Med.Chem. 37 1889 PMID: 8021930
Carriero et al (1998) A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing. Psychopharmacology (Berl.) 137 147 PMID: 9630001
Khanolkar et al (1996) Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. J.Med.Chem. 39 4515 PMID: 8893848
Zygmunt et al (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400 452 PMID: 10440374
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关键词: (R)-(+)-Methanandamide, (R)-(+)-Methanandamide supplier, Potent, selective, CB1, agonists, Cannabinoids, Receptors, cb1r, 1121, Tocris Bioscience
7 篇 (R)-(+)-Methanandamide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (R)-(+)-Methanandamide 的部分引用包括：
Grace et al (2014) Identification of a pharmacological target for genioglossus reactivation throughout sleep. Nat Chem Biol 37 41 PMID: 24470694
Korossy-Mruk et al (2013) Neonatal DSP-4 treatment modifies antinociceptive effects of the CB1 receptor agonist methanandamide in adult rats. Neurotox Res 23 39 PMID: 22488162
Mendiguren and Pineda (2009) Effect of the CB(1) receptor antagonists rimon. and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices. Br J Pharmacol 158 1579 PMID: 19845674
Carney et al (2009) Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells. J Neuroimmune Pharmacol 4 338 PMID: 19365734
Justinova et al (2008) Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimon. Neuropsychopharmacology 33 2870 PMID: 18305459
Cenni et al (2006) Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain. Eur J Neurosci 24 1633 PMID: 17004927
Nieri et al (2006) Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells. Br J Pharmacol 148 682 PMID: 16715117
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Low affinity CB1 agonist.
By
Jonathan Fay on 05/30/2019
分析类型： In Vitro
种属： Human
细胞系/组织： COSH-1
Used as an agonist to induce a spectroscopic change of a fluorescent reporter attached to trans-membrane helix six of purified CB1.
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