(R)-(-)-Niguldipine hydrochloride

Name: ( R )-(-)-Niguldipine hydrochloride
Brand: Tocris Bioscience
SKU: 1124

Cat. No. 1124 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1124 has been discontinued.

View all Adrenergic α<sub>1</sub> Receptors products.

说明： α₁ antagonist, L-type Ca²⁺ channel blocker. Less active enantiomer of Niguldipine hydrochloride (Cat. No. 1123)

化学名： (R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride

说明书

引用文献

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生物活性技术数据说明书参考文献

生物活性 for (R)-(-)-Niguldipine hydrochloride

(R)-(-)-Niguldipine hydrochloride is a L-type Ca²⁺ channel blocker and α_1A-adrenoceptor antagonist; less active enantiomer.

S-enantiomer also available.

技术数据 for (R)-(-)-Niguldipine hydrochloride

分子量	646.18
公式	C₃₆H₃₉N₃O₆.HCl
储存	Desiccate at -20°C
CAS Number	113145-70-3
PubChem ID	16219720
InChI Key	MHOSUIMBPQVOEU-WAQYZQTGSA-N
Smiles	O=C(OC)C1=C(C)NC(C)=C(C(OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3)=O)[C@@H]1[C@]2=CC=CC([N+]([O-])=O)=C2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (R)-(-)-Niguldipine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (R)-(-)-Niguldipine hydrochloride

参考文献是支持产品生物活性的出版物。

Boer et al (1989) (+)-Niguldipine binds with very high affinity to Ca²⁺ channels and to a subtype of alpha₁-adrenoceptor. Eur.J.Pharmacol. 172 131 PMID: 2548881

Graziadei et al (1989) Stereoselective binding of niguldipine enantiomers to alpha_1A-adrenoceptors labeled with [³H]5-methyl-urapidil. Eur.J.Pharmacol. 172 329 PMID: 2555206

Hollt et al (1992) Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 43 2601 PMID: 1352973

Wetzel et al (1995) Discovery of alpha_1a-adrenergic receptor antagonists based on the L-type Ca²⁺ channel antagonist niguldipine. J.Med.Chem. 38 1579 PMID: 7752182

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