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(R)-(-)-Phenylephrine hydrochloride

Cat. No. 2838 4 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： α1 agonist
化学名： (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论 (1)
文献 (1)
生物活性 Scientific Data 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (R)-(-)-Phenylephrine hydrochloride

(R)-(-)-Phenylephrine hydrochloride is a α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

Scientific Data

Binding Activity phenylephrine affects cardiomyocyte contraction rates View Larger

Small molecules affect cardiomyocyte contraction rates. The effect of small molecules on cardiomyocyte contraction rate was assessed by monitoring intracellular calcium fluctuations, where an increase in calcium coincides with cardiomyocyte contraction. Cardiomyocytes were loaded with the fluorescent calcium indicator, Fluo-4, prior to small molecule treatment. Individual wells were first monitored for baseline rates of calcium fluctuation represented as beats per minute (bpm). Phenylephrine (3μM, Catalog # 2838), an alpha 1-adrenoceptor agonist, increased the calcium fluctuation rate of cardiomyocytes compared to untreated cells

化合物库 for (R)-(-)-Phenylephrine hydrochloride

(R)-(-)-Phenylephrine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for (R)-(-)-Phenylephrine hydrochloride

分子量 203.67
公式 C9H13NO2.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 61-76-7
PubChem ID 441279
InChI Key OCYSGIYOVXAGKQ-FVGYRXGTSA-N
Smiles OC1=CC=CC([C@@H](O)CNC)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (R)-(-)-Phenylephrine hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 20.37 100
DMSO 20.37 100

制备储备液 for (R)-(-)-Phenylephrine hydrochloride

以下数据基于产品分子量 203.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.91 mL 24.55 mL 49.1 mL
5 mM 0.98 mL 4.91 mL 9.82 mL
10 mM 0.49 mL 2.45 mL 4.91 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

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产品说明书 for (R)-(-)-Phenylephrine hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for (R)-(-)-Phenylephrine hydrochloride

参考文献是支持产品生物活性的出版物。

Minneman et al (1994) Selectivity of agonists for cloned α1-adrenergic receptor subtypes. Mol.Pharmacol. 46 929 PMID: 7969082

Ford et al (1997) Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification. Br.J.Pharmacol. 121 1127 PMID: 9249248

Morton et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072

If you know of a relevant reference for (R)-(-)-Phenylephrine hydrochloride, please let us know.

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关键词: (R)-(-)-Phenylephrine hydrochloride, (R)-(-)-Phenylephrine hydrochloride supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, agonists, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, Receptors, Adrenergic, Alpha-1, 2838, Tocris Bioscience

4 篇 (R)-(-)-Phenylephrine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (R)-(-)-Phenylephrine hydrochloride 的部分引用包括：

Li et al (2016) Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway. PLoS One 11 e0159079 PMID: 27438013

Jin et al (2015) Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus. J Neurosci 10 e0126956 PMID: 25962147

Lam et al (2011) Leptin does not directly affect CNS serotonin neurons to influence appetite. PLoS One 13 584 PMID: 21531340

Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653

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(R)-(-)-Phenylephrine hydrochloride 的评论

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Adrenergic agonist.
By Anonymous on 10/02/2018
分析类型： In Vivo
种属： Mouse

Elicits calcium increase in astrocytes at 100uM

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