Raloxifene hydrochloride

Cat. No. 2280 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective estrogen receptor modulator (SERM)

别名： LY 139481,Keoxifene

化学名： [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride

纯度： ≥98% (HPLC)

引用文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Raloxifene hydrochloride

Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM) that binds to ERα and ERβ, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC₅₀ of 1 nM.

化合物库 for Raloxifene hydrochloride

Raloxifene hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Raloxifene hydrochloride

分子量	510.04
公式	C₂₈H₂₇NO₄S.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	82640-04-8
PubChem ID	54900
InChI Key	BKXVVCILCIUCLG-UHFFFAOYSA-N
Smiles	Cl.OC1=CC=C(C=C1)C1=C(C(=O)C2=CC=C(OCCN3CCCCC3)C=C2)C2=CC=C(O)C=C2S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Raloxifene hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	25.5	50

制备储备液 for Raloxifene hydrochloride

以下数据基于产品分子量 510.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.92 mL	19.61 mL	39.21 mL
2.5 mM	0.78 mL	3.92 mL	7.84 mL
5 mM	0.39 mL	1.96 mL	3.92 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

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产品说明书 for Raloxifene hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Raloxifene hydrochloride

参考文献是支持产品生物活性的出版物。

Fitzpatrick et al (1999) Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line. Endocrinology 140 3928 PMID: 10465261

Bryant (2001) Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator. Rev.Endocr.Metab.Disord. 2 129 PMID: 11704975

Hibner et al (2004) Effects of ralox. hydrochloride on endometrial cancer cells in vitro. Gynecologic Oncol. 93 642

Todorova (2011) Tamoxifen and ralox. suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 67 285 PMID: 20383709

If you know of a relevant reference for Raloxifene hydrochloride, please let us know.

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Estrogen and Related Receptors

关键词: Raloxifene hydrochloride, Raloxifene hydrochloride supplier, Selective, estrogen, receptor, modulators, SERM, ER, Estrogen, Receptors, LY139481, amino, acid, transporter, 2, ASCT2, LY, 139481, Keoxifene, and, Related, 2280, Tocris Bioscience

2 篇 Raloxifene hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Raloxifene hydrochloride 的部分引用包括：

Morikawa et al (2022) Pharmacological characterization of AS2690168, a novel small molecule RANKL signal transduction inhibitor. Eur.J.Pharmacol. 924 174941 PMID: 35398031

Nicholson et al (2015) Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia. Am J Physiol Heart Circ Physiol 193 722 PMID: 25167991

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