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Submit ReviewRauwolscine hydrochloride
Discontinued Product
0891 has been discontinued.
View all Adrenergic α<sub>2</sub> Receptors products.
说明： α2 antagonist
别名： α-Yohimbine hydrochloride,Corynanthidine
化学名： 17α-Hydroxy-20α-yohimban-16β-carboxylic acid,methyl ester hydrochloride
纯度： ≥95% (HPLC)
生物活性 for Rauwolscine hydrochloride
Rauwolscine hydrochloride is a standard α2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A, α2B, and α2C-adrenoceptors respectively). Partial agonist at 5-HT1A receptors.
Diastereomer also avilable.
技术数据 for Rauwolscine hydrochloride
| 分子量 | 390.91 |
| 公式 | C21H26N2O3.HCl |
| 储存 | Store at RT |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 6211-32-1 |
| PubChem ID | 197067 |
| InChI Key | PIPZGJSEDRMUAW-ZKKXXTDSSA-N |
| Smiles | [H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@]3([H])[C@]([C@H]([C@](OC)=O)[C@@H](O)CC3)([H])C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Rauwolscine hydrochloride
参考文献 for Rauwolscine hydrochloride
参考文献是支持产品生物活性的出版物。
Arthur et al (1993) Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors. Biochem.Pharmacol. 45 2337 PMID: 8517875
Hieble et al (1995) β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428
Uhlen et al (1998) [3H]RS79948-197 binding to human, rat, guinea pig and pig α2A-, α2B-, and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 343 93 PMID: 9551719
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关键词: Rauwolscine hydrochloride, Rauwolscine hydrochloride supplier, α2-adrenoceptor, alpha2-adrenoceptor, antagonists, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, a2-adrenergic, Receptors, alpha-Yohimbine, hydrochloride, a-Yohimbine, Corynanthidine, Adrenergic, Alpha-2, 0891, Tocris Bioscience
2 篇 Rauwolscine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Rauwolscine hydrochloride 的部分引用包括：
Moura et al (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol 149 1049 PMID: 17075569
Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. J Neurosci 24 7745 PMID: 15342742
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.