RC 160

Discontinued Product

3139 has been discontinued.

View all Somatostatin (sst) Receptors products.
说明: sst analog
别名: Vapreotide
说明书
引用文献
评论

生物活性 for RC 160

RC 160 is a cyclic octapeptide somatostatin analog (Ki values are 0.7, 5.4, 30.9, 45 and > 1000 nM for sst5, sst2, sst3, sst4 and sst1 receptors respectively). More metabolically stable than somatostatin (Cat. No. 1157). Inhibits growth hormone release in vivo.

技术数据 for RC 160

分子量 1131.37
公式 C57H70N12O9S2
序列 FCYWKVCW

(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Trp-8 = C-terminal amide, Disulfide bridge between 2 - 7)

储存 Desiccate at -20°C
CAS Number 103222-11-3
PubChem ID 6918026
InChI Key SWXOGPJRIDTIRL-DOUNNPEJSA-N
Smiles [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RC 160

分析证书/产品说明书
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参考文献 for RC 160

参考文献是支持产品生物活性的出版物。

Karashima et al (1987) Effects of highly potent octapeptide analogs of somatostatin on GH, Ins and glucagon release. Life Sci. 41 1011 PMID: 2886886

Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five coned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814 PMID: 7988476

Lahlou et al (2003) sst2 Somatostatin receptor inhibits cell proliferation through Ras- Rap1-, and B-raf-dependent ERK2 activation. J.Biol.Chem. 278 39356 PMID: 12878607

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关键词: RC 160, RC 160 supplier, Somatostatin, sst, Receptors, RC160, Vapreotide, 3139, Tocris Bioscience

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