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Submit ReviewRC 160 is a cyclic octapeptide somatostatin analog (Ki values are 0.7, 5.4, 30.9, 45 and > 1000 nM for sst5, sst2, sst3, sst4 and sst1 receptors respectively). More metabolically stable than somatostatin (Cat. No. 1157). Inhibits growth hormone release in vivo.
分子量 | 1131.37 |
公式 | C57H70N12O9S2 |
序列 |
FCYWKVCW (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Trp-8 = C-terminal amide, Disulfide bridge between 2 - 7) |
储存 | Desiccate at -20°C |
CAS Number | 103222-11-3 |
PubChem ID | 6918026 |
InChI Key | SWXOGPJRIDTIRL-DOUNNPEJSA-N |
Smiles | [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Karashima et al (1987) Effects of highly potent octapeptide analogs of somatostatin on GH, Ins and glucagon release. Life Sci. 41 1011 PMID: 2886886
Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five coned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814 PMID: 7988476
Lahlou et al (2003) sst2 Somatostatin receptor inhibits cell proliferation through Ras- Rap1-, and B-raf-dependent ERK2 activation. J.Biol.Chem. 278 39356 PMID: 12878607
关键词: RC 160, RC 160 supplier, Somatostatin, sst, Receptors, RC160, Vapreotide, 3139, Tocris Bioscience
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