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Remodelin

Cat. No. 5193 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： N-acetyltransferase 10 (NAT10) inhibitor
化学名： 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Remodelin

Remodelin is a N-acetyltransferase 10 (NAT10) inhibitor. Improves nuclear shape in HGPS (Hutchinson-Gilford progeria syndrome) cells and lamin A/C depleted cells.

技术数据 for Remodelin

分子量 282.36
公式 C15H14N4S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 949912-58-7
PubChem ID 44442376
InChI Key XAEJIFARBQJLML-UHFFFAOYSA-N
Smiles N#CC(C=C1)=CC=C1C2=CSC(N/N=C3CCCC/3)=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Remodelin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.24 100

制备储备液 for Remodelin

以下数据基于产品分子量 282.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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参考文献 for Remodelin

参考文献是支持产品生物活性的出版物。

Larrieu et al (2014) Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344 527 PMID: 24786082

If you know of a relevant reference for Remodelin, please let us know.

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关键词: Remodelin, Remodelin supplier, NAT10, N-acetyltransferase, 10, aging, inhibitors, HGPS, Hutchinson-Gilford, progeria, syndrome, laminopathies, laminopathy, inhibits, Other, Transferases, 5193, Tocris Bioscience

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