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Submit ReviewRemoxipride hydrochloride
说明： Selective D2-like antagonist
化学名： (S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamide hydrochloride
生物活性 for Remoxipride hydrochloride
Remoxipride hydrochloride is a dopamine D2 receptor antagonist showing selectivity over D3 and D4 receptors (Ki values are ~ 300, ~ 1600, and ~ 2800 nM for D2, D3 and D4 receptors respectively). Exhibits antipsychotic activity in vivo with no extrapyramidal side effects. 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.
技术数据 for Remoxipride hydrochloride
| 分子量 | 407.73 |
| 公式 | C16H23BrN2O3.HCl |
| 储存 | Store at RT |
| CAS Number | 73220-03-8 |
| PubChem ID | 15565709 |
| InChI Key | WCPXLMIPGMFZMY-MERQFXBCSA-N |
| Smiles | BrC1=CC=C(OC)C(C(NC[C@@]2(CCCN2CC)[H])=O)=C1OC.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Remoxipride hydrochloride
参考文献 for Remoxipride hydrochloride
参考文献是支持产品生物活性的出版物。
Ahlenius et al (1997) In vivo effects of remoxipride and aromatic ring metabolites in the rat. J.Pharmacol.Exp.Ther. 283 1356 PMID: 9400011
Mohell et al (1993) Binding characteristics of remoxipride and its metabolites to DA D2 and D3 receptors. Eur.J.Pharmacol. 238 121 PMID: 8405075
Sedvall (1990) Development of a new antipsychotic remoxipride. Acta Psychiatr.Scand.Suppl. 358 1 PMID: 1978466
Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991
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关键词: Remoxipride hydrochloride, Remoxipride hydrochloride supplier, selective, D2-like, antagonists, dopamine, non-selective, receptor, antagonist, dopaminergic, d2, Non-selective, Dopamine, 0916, Tocris Bioscience
1 篇 Remoxipride hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Remoxipride hydrochloride 的部分引用包括：
André et al (2011) Differential electrophysiological changes in striatal output neurons in Huntington's disease. J Neurosci 31 1170 PMID: 21273402
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.