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Submit ReviewReserpine
说明： Inhibitor of vesicular monoamine transport
化学名： (3β,16β,17α,18β,20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
纯度： ≥99% (HPLC)
生物活性 for Reserpine
Binds the vesicular monoamine transporter (VMAT2) and inhibits transport of biogenic amines into adrenal chromaffin granules and synaptic vesicles. Causes depletion of biogenic amine stores. Antihypertensive and antipsychotic.
技术数据 for Reserpine
| 分子量 | 608.68 |
| 公式 | C33H40N2O9 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 50-55-5 |
| PubChem ID | 5770 |
| InChI Key | QEVHRUUCFGRFIF-MDEJGZGSSA-N |
| Smiles | [H][C@@](N4CC3)(C[C@@]([C@H]([C@@](OC)=O)[C@@H](OC)[C@H](OC(C6=CC(OC)=C(OC)C(OC)=C6)=O)C5)([H])[C@@]5([H])C4)C2=C3C1=C(N2)C=C(OC)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Reserpine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 6.09 | 10 |
制备储备液 for Reserpine
以下数据基于产品分子量 608.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.43 mL | 82.14 mL | 164.29 mL |
| 0.5 mM | 3.29 mL | 16.43 mL | 32.86 mL |
| 1 mM | 1.64 mL | 8.21 mL | 16.43 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.29 mL |
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产品说明书 for Reserpine
参考文献 for Reserpine
参考文献是支持产品生物活性的出版物。
Schuldiner et al (1993) Reserpine binding to a vesicular amine transporter expressed in chinese hamster ovary fibroblasts. J.Biol.Chem. 268 29 PMID: 8416935
Heslop and Curzon (1999) Effect of rese. on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes. Neuropharmacology 38 883 PMID: 10465692
Metzger et al (2002) Inhibitory effect of rese. on DA transporter function. Eur.J.Pharmacol. 456 39 PMID: 12450567
If you know of a relevant reference for Reserpine, please let us know.
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关键词: Reserpine, Reserpine supplier, inhibitors, inhibits, vesicular, monoamine, transporters, Noradrenalin, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, DAT, Dopamine, Serotonin, SERT, 5-HT, reuptake, 5-Hydroxytryptamine, VMAT2, noradrenaline, Vesicular, 2742, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Reserpine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
4 篇 Reserpine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Reserpine 的部分引用包括：
Njagi et al (2010) Electrochemical quantification of serotonin in the live embryonic zebrafish intestine. Anal Chem 82 1822 PMID: 20148518
Prado et al (2012) Stimulation of DA receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. Cell Tissue Res 188 3062 PMID: 22379034
Berrios et al (2016) Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation. Neuropsychopharmacology 7 10702 PMID: 26869263
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. J Immunol 40 766 PMID: 25249058
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Reserpine 的评论
平均评分: 5 (Based on 1 Review.)
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Reserpine as a VMAT bloker to depleted the endogenous DA in mouse striatum.
By
Benoit Delignat-Lavaud on 01/04/2018
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： striatum slices
This product work super fine in electrophysiology for blocking the VMAT. We currently use it at the concentration of 5 µM in normal ACSF.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.