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Retigabine

Cat. No. 6233 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： KV7 channel activator
别名： Ezogabine
化学名： Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Retigabine

Retigabine is a KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.

技术数据 for Retigabine

分子量 303.33
公式 C16H18FN3O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 150812-12-7
PubChem ID 121892
InChI Key PCOBBVZJEWWZFR-UHFFFAOYSA-N
Smiles CCOC(NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Retigabine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.33 100
ethanol 30.33 100

制备储备液 for Retigabine

以下数据基于产品分子量 303.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.3 mL 16.48 mL 32.97 mL
5 mM 0.66 mL 3.3 mL 6.59 mL
10 mM 0.33 mL 1.65 mL 3.3 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for Retigabine

参考文献是支持产品生物活性的出版物。

Blackburn-Munro et al (2005) Retigabine: chemical synthesis to clinical application. CNS Drug Rev. 11 1 PMID: 15867950

If you know of a relevant reference for Retigabine, please let us know.

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关键词: Retigabine, Retigabine supplier, potassium, channel, openers, activators, activates, M, current, anticonvulsant, Kv7, KCNQ, orally, bioavailable, Ezogabine, Voltage-Gated, Potassium, Channels, 6233, Tocris Bioscience

1 篇 Retigabine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Retigabine 的部分引用包括：

Afeli et al (2013) Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle. PLoS One 8 e75875 PMID: 24073284

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Retigabine 的评论

平均评分: 5 (Based on 1 Review.)

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Retigabine studied on HEK 293 cell line : Worked ideally on experimental conditions.
By Farzana Islam on 09/02/2018
种属： Human
细胞系/组织： HEK 293

The aim of my study was to determine if Retigabine shows BK channel activation on Human Embryonic Kidney (HEK 293) cells, when compared to the standard BK activation of NS1619, carried out using non-radioactive Rubidium efflux method and analysed by Flame AAS. 100µM,10µM NS1619,1µM NS1619 and 0.1µM Retigabine concentrations have been used for the study and it performed well under experimental conditions. Graphs show Rubidium efflux percentage observed with Retigabine.

For sterile test compound, dissolve Retigabine in sterile DMSO under a hood.

review image