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RETRA hydrochloride

Cat. No. 3214 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3214 has been discontinued.

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说明： Antitumor agent; suppresses mutant p53-bearing cancer cells
化学名： 2-[(4,5-Dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)ethanone hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献
评论
文献 (2)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for RETRA hydrochloride

RETRA hydrochloride is an antitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.

技术数据 for RETRA hydrochloride

分子量 305.8
公式 C11N11NO3S2.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 1173023-52-3
PubChem ID 46861546
InChI Key ZZAVDVMJZKDBIB-UHFFFAOYSA-N
Smiles OC1=CC(C(CSC2=NCCS2)=O)=CC=C1O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RETRA hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for RETRA hydrochloride

参考文献是支持产品生物活性的出版物。

Kravchenko et al (2008) Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc.Natl.Acad.Sci.USA 105 6302

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关键词: RETRA hydrochloride, RETRA hydrochloride supplier, Antitumor, agent, suppresses, mutant, p53-bearing, Transcription, Factors, p73, p53, 3214, Tocris Bioscience

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该领域的文献

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for RETRA hydrochloride

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.