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说明： Selective MRP1 and P-gp inhibitor
化学名： N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
纯度： ≥95% (HPLC)
生物活性 for Reversan
Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.
化合物库 for Reversan
Reversan is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Reversan
| 分子量 | 441.52 |
| 公式 | C26H27N5O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 313397-13-6 |
| PubChem ID | 2298706 |
| InChI Key | JTRXWCLQFAZHGP-UHFFFAOYSA-N |
| Smiles | O=C(NCCCN5CCOCC5)C2=C1N=C(C4=CC=CC=C4)C=C(C3=CC=CC=C3)N1N=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Reversan
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 11.04 | 25 |
制备储备液 for Reversan
以下数据基于产品分子量 441.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 9.06 mL | 45.3 mL | 90.6 mL |
| 1.25 mM | 1.81 mL | 9.06 mL | 18.12 mL |
| 2.5 mM | 0.91 mL | 4.53 mL | 9.06 mL |
| 12.5 mM | 0.18 mL | 0.91 mL | 1.81 mL |
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产品说明书 for Reversan
参考文献 for Reversan
参考文献是支持产品生物活性的出版物。
Burkhart et al (2009) Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 69 6573 PMID: 19654298
If you know of a relevant reference for Reversan, please let us know.
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关键词: Reversan, Reversan supplier, MRP1, p-glycoprotein, p-gp, multidrug, resistance, associated, protein, 1, transporters, inhibitors, inhibits, selective, ABCB1, Multidrug, Transporters, 3722, Tocris Bioscience
1 篇 Reversan 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Reversan 的部分引用包括：
James E et al (2020) Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines. Int J Mol Sci 21 PMID: 33081264
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Reversan 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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