RFRP-1 (human)

Name: RFRP-1 (human)
Brand: Tocris Bioscience
SKU: 5677

Cat. No. 5677 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5677 has been discontinued.

View all Neuropeptide FF/AF Receptors products.

说明： Potent NPFF receptor agonist

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for RFRP-1 (human)

RFRP-1 (human) is a potent endogenous NPFF receptor agonist (EC₅₀ values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats. GnIH homolog.

技术数据 for RFRP-1 (human)

分子量	1428.72
公式	C₆₇H₁₀₁N₁₉O₁₄S
序列	MPHSFANLPLRF (Phe-12 = C-terminal amide)
储存	Store at -20°C
CAS Number	311309-25-8
PubChem ID	71462794
InChI Key	STXUPUZSJMRDJT-IWPKOFGPSA-N
Smiles	[H]N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RFRP-1 (human)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RFRP-1 (human)

参考文献是支持产品生物活性的出版物。

Gouardères et al (2006) Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [³⁵S]GTPγS binding. Neuropharmacology 52 376 PMID: 17011599

Nichols et al (2010) Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. Peptides 31 2067 PMID: 20797420

Hinuma et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell.Biol. 2 703 PMID: 11025660

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关键词: RFRP-1 (human), RFRP-1 (human) supplier, neuropeptide, FF, receptors, NPFF1, NPFF2, GPR147, prolactin, RFamide-related, peptides, cardiac, myocytes, agonists, agonism, endogenous, Neuropeptide, FF/AF, Receptors, 5677, Tocris Bioscience

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