RHPS 4 methosulfate

Cat. No. 5311 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Telomerase inhibitor

化学名： 3,11-Difluoro-6,8,13-trimethylquino[4,3,2-kl]acridinium methylsulfate

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for RHPS 4 methosulfate

RHPS 4 methosulfate is a telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice. Sensitizes radiation resistant glioblastoma cell lines to radiation.

技术数据 for RHPS 4 methosulfate

分子量	458.48
公式	C₂₂H₁₇F₂N₂.CH₃O₄S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	390362-78-4
PubChem ID	9804187
InChI Key	VRWGYMXWYZBBGF-UHFFFAOYSA-M
Smiles	C[N+]4=C2C3=C(C=C(C)C=C3C5=C4C=CC(F)=C5)N(C)C1=CC=C(F)C=C12.COS(=O)([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RHPS 4 methosulfate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	4.58	10 温和加热
	DMSO	9.17	20

制备储备液 for RHPS 4 methosulfate

以下数据基于产品分子量 458.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	10.91 mL	54.53 mL	109.06 mL
1 mM	2.18 mL	10.91 mL	21.81 mL
2 mM	1.09 mL	5.45 mL	10.91 mL
10 mM	0.22 mL	1.09 mL	2.18 mL

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产品说明书 for RHPS 4 methosulfate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RHPS 4 methosulfate

参考文献是支持产品生物活性的出版物。

Lagah et al (2014) RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS One 9 e86187 PMID: 24454961

Salvati et al (2007) Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J.Clin.Invest. 117 3236 PMID: 17932567

Phatak et al (2007) Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br.J.Cancer 96 1223 PMID: 17406367

Berardinelli et al (2015) The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells. DNA Repair (Amst.) 25 104 PMID: 25467559

If you know of a relevant reference for RHPS 4 methosulfate, please let us know.

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