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Ribavirin

Cat. No. 4501 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Blocks eIF4E activity; antiviral guanosine analog
化学名： 1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ribavirin

Ribavirin is an antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (Ki ~ 0.3 μM for the active metabolite, ribavirin triphosphate). Also inosine monophosphate dehydrogenase (IMPDH) inhibitor. Represses colony formation of primary AML-M5 progenitor cells (IC50 ~ 1 μM); reduces disease severity in acute myeloid leukemia (AML). Inhibits cytopathic effect of SARS-CoV in Vero cells in vitro. Orally available.

化合物库 for Ribavirin

Ribavirin is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Ribavirin

分子量 244.2
公式 C8H12N4O5
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 36791-04-5
PubChem ID 37542
InChI Key IWUCXVSUMQZMFG-AFCXAGJDSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O)=N2)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ribavirin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 24.42 100
DMSO 24.42 100

制备储备液 for Ribavirin

以下数据基于产品分子量 244.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.1 mL 20.48 mL 40.95 mL
5 mM 0.82 mL 4.1 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.1 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

Molarity Calculator

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Reconstitution Calculator

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产品说明书 for Ribavirin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Ribavirin

参考文献是支持产品生物活性的出版物。

Kentsis et al (2004) Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc.Natl.Acad.Sci.U.S.A. 101 18105 PMID: 15601771

Assouline et al (2009) Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with riba. Blood 114 257 PMID: 19433856

Tan et al (2004) Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs. Emerg.Infect.Dis. 10 581 PMID: 15200845

Graci and Cameron (2006) Mechanisms of action of ribavirin against distinct viruses. Rev.Med.Virol. 16 37 PMID: 16287208

If you know of a relevant reference for Ribavirin, please let us know.

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关键词: Ribavirin, Ribavirin supplier, broad, spectrum, antivirals, guanosine, ribonucleoside, analogues, analogs, mammalian, eIF4E, inhibits, inhibitors, translocation, cellular, redistribution, virazole, IMPDH, inosine, monophosphate, dehydrogenase, COVID-19, SARS-CoV, severe, acute, respirator, DNA,, RNA, and, Protein, Synthesis, Protein-synthesizing, GTPases, Other, Dehydrogenases, Polymerase, Non-selective, Antivirals, Coronavirus, 4501, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Ribavirin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

篇 Ribavirin 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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Ribavirin 的评论

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Used as an IMPDH inhibitor.
By Timothy Ryan on 09/30/2024
分析类型： Ex Vivo
种属： Rat
细胞系/组织： Primary hippocampal neurons

The drug was incubated at 2 μM for 2 h to deplete intracellular GTP.