Rimcazole dihydrochloride

Cat. No. 1497 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： σ₂ antagonist. Also DAT inhibitor

别名： BW 234U

化学名： 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)propyl]-9H-carbazole dihydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Rimcazole dihydrochloride

Rimcazole dihydrochloride is an antagonist at σ receptors (IC₅₀ values are 1480 and 386 nM at σ₁ and σ₂ receptors respectively). Also binds to the dopamine transporter (IC₅₀ = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo.

技术数据 for Rimcazole dihydrochloride

分子量	394.39
公式	C₂₁H₂₇N₃.2HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	75859-03-9
PubChem ID	53388
InChI Key	ZWHRZGHGYMUSRM-VWDRLOGHSA-N
Smiles	C[C@H](N[C@H](C)C4)CN4CCCN1C3=C(C=CC=C3)C2=C1C=CC=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Rimcazole dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	3.94	10

制备储备液 for Rimcazole dihydrochloride

以下数据基于产品分子量 394.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	25.36 mL	126.78 mL	253.56 mL
0.5 mM	5.07 mL	25.36 mL	50.71 mL
1 mM	2.54 mL	12.68 mL	25.36 mL
5 mM	0.51 mL	2.54 mL	5.07 mL

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产品说明书 for Rimcazole dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Rimcazole dihydrochloride

参考文献是支持产品生物活性的出版物。

Ferris et al (1986) Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life Sci. 38 2329 PMID: 2873494

Husbands et al (1997) Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the DA transporter. J.Med.Chem. 40 4340 PMID: 9435903

Matsumoto et al (2001) Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than DA transporters. Neuropharmacology 41 878 PMID: 11684152

If you know of a relevant reference for Rimcazole dihydrochloride, please let us know.

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关键词: Rimcazole dihydrochloride, Rimcazole dihydrochloride supplier, σ2, sigma2, antagonists, DAT, reuptake, inhibitors, inhibits, Receptors, Dopamine, Transporters, Monoamine, Neurotransmitter, BW234U, BW, 234U, Sigma2, 1497, Tocris Bioscience

1 篇 Rimcazole dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Rimcazole dihydrochloride 的部分引用包括：

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788

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