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RIPA 56

Cat. No. 7339 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and metabolically stable RIP1 kinase inhibitor
化学名： N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RIPA 56

RIPA 56 is a potent and metabolically stable receptor-interacting protein kinase 1 (RIPK1) inhibitor (EC50 = 13 nM). RIPA-56 shows no inhibition of RIP3 kinase at 10 μM. RIPA 56 blocks necroptosis and aging of the mouse male reproductive system. RIPA 56 reduces tumor necrosis factor α (TNFα)-induced mortality and multi-organ damage in a mouse model of systemic inflammatory response syndrome (SIRS). RIPA 56 is orally bioavailable.

化合物库 for RIPA 56

RIPA 56 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for RIPA 56

分子量 221.3
公式 C13H19NO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1956370-21-0
PubChem ID 121439991
InChI Key AVYVHIKSFXVDBG-UHFFFAOYSA-N
Smiles O=C(N(O)CC=1C=CC=CC1)C(C)(C)CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RIPA 56

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.13 100
ethanol 22.13 100

制备储备液 for RIPA 56

以下数据基于产品分子量 221.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.52 mL 22.59 mL 45.19 mL
5 mM 0.9 mL 4.52 mL 9.04 mL
10 mM 0.45 mL 2.26 mL 4.52 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

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参考文献 for RIPA 56

参考文献是支持产品生物活性的出版物。

Li et al (2017) RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. Elife 6 e27692 PMID: 28807105

Ren et al (2017) Discovery of a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) for the treatment of systemic inflammatory response syndrome. J.Med.Chem. 60 972 PMID: 27992216

Zhuang et al (2019) Small-molecule inhibitors of necroptosis: current status and perspectives. J.Med.Chem. 63 1490 PMID: 31622096

If you know of a relevant reference for RIPA 56, please let us know.

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关键词: RIPA 56, RIPA 56 supplier, RIPA56, necroptosis, RIP1, inhibits, inhibitors, RIPK, RIPK1, receptor-interacting, protein, kinase, 1, kinases, RIP, Kinases, Necroptosis, 7339, Tocris Bioscience

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