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Risperidone

Cat. No. 2865 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： 5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
别名： R 64 766
化学名： 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论 (1)
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Risperidone

Risperidone is an atypical antipsychotic agent that displays 5-HT2A receptor antagonism. Also displays high affinity at D2 receptors (Ki values are 0.4 and 3.13 nM for 5-HT2A and D2 receptors respectively).

技术数据 for Risperidone

分子量 410.48
公式 C23H27FN4O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 106266-06-2
PubChem ID 5073
InChI Key RAPZEAPATHNIPO-UHFFFAOYSA-N
Smiles FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(CCCC5)N5C4=O)CC3)=NO2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Risperidone

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.1 10
ethanol 4.1 10

制备储备液 for Risperidone

以下数据基于产品分子量 410.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 24.36 mL 121.81 mL 243.62 mL
0.5 mM 4.87 mL 24.36 mL 48.72 mL
1 mM 2.44 mL 12.18 mL 24.36 mL
5 mM 0.49 mL 2.44 mL 4.87 mL

Molarity Calculator

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Reconstitution Calculator

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参考文献 for Risperidone

参考文献是支持产品生物活性的出版物。

Leysen et al (1988) Biochemical profile of risperidone, a new antipsychotic. J.Pharmacol.Exp.Ther. 247 661 PMID: 2460616

Leysen et al (1994) Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 55 5 PMID: 7520908

Stathis et al (1996) Risperidone: a novel antipsychotic with many "atypical" properties. Psychopharmacol. 127 181

Wang et al (2018) Structure of the D2 DA receptor bound to the atypical antipsychotic drug risperidone Nature 555 269 PMID: 29466326

If you know of a relevant reference for Risperidone, please let us know.

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关键词: Risperidone, Risperidone supplier, 5-HT2A, antagonists, D2, Serotonin, Receptors, Dopamine, dopaminergic, R64766, R, 64, 766, 2865, Tocris Bioscience

2 篇 Risperidone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Risperidone 的部分引用包括：

Kurita et al (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci 15 1245 PMID: 22864611

Canfrán-Duque et al (2015) Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. Sci Rep 10 e0141829 PMID: 26517556

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Risperidone 的评论

平均评分: 4 (Based on 1 Review.)

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Risperidone effects in mice hyperactivity.
By Anonymous on 01/11/2019
分析类型： In Vivo
种属： Mouse

We found that risperidone treatment decreased hyperactivity of NF-kappa B p50 subunit KO mice, but had no effect on defective social interaction. Altogether, these data add complexity to a growing body of data, suggesting a link between dysregulation of the NF-kappa B pathway and neurodevelopmental disorders pathogenesis.

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