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Submit ReviewRitanserin
说明： Potent 5-HT2 antagonist
化学名： 6-[2-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
纯度： ≥98% (HPLC)
生物活性 for Ritanserin
Ritanserin is a potent and long-acting 5-HT2 receptor antagonist (Ki = 0.39 nM). Anxiolytic in vivo.
化合物库 for Ritanserin
Ritanserin is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Ritanserin
| 分子量 | 477.57 |
| 公式 | C27H25F2N3OS |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 87051-43-2 |
| PubChem ID | 5074 |
| InChI Key | JUQLTPCYUFPYKE-UHFFFAOYSA-N |
| Smiles | O=C1N3C(SC=C3)=NC(C)=C1CCN4CC/C(CC4)=C(C5=CC=C(F)C=C5)/C2=CC=C(F)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ritanserin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 11.94 | 25 | |
| DMSO | 47.76 | 100 |
制备储备液 for Ritanserin
以下数据基于产品分子量 477.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.47 mL | 20.94 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.19 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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产品说明书 for Ritanserin
参考文献 for Ritanserin
参考文献是支持产品生物活性的出版物。
Janssen (1985) Pharmacology of potent and selective S2-serotonergic antagonists. J.Cardiovasc.Pharmacol. 7 S2 PMID: 2412048
Leysen et al (1985) Receptor-binding properties in vitro and in vivo of ritanserin. Mol.Pharmacol. 27 600 PMID: 2860558
Watanabe et al (1992) Syntheses and 5-HT2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivatives. J.Med.Chem. 35 189 PMID: 1732528
If you know of a relevant reference for Ritanserin, please let us know.
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关键词: Ritanserin, Ritanserin supplier, Potent, 5-HT2, antagonists, Non-Selective, Serotonin, Receptors, Non-selective, 1955, Tocris Bioscience
7 篇 Ritanserin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ritanserin 的部分引用包括：
Bracha et al (2013) The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line. Physiol Behav 9 251 PMID: 24330646
Shimizu et al (2017) Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HT7 receptors in rats. Br J Pharmacol 174 3072 PMID: 28675470
Alsene and Bakshi (2011) Pharmacological stimulation of locus coeruleus reveals a new antipsychotic-responsive pathway for deficient sensorimotor gating. Neuropsychopharmacology 36 1656 PMID: 21508929
Mondal et al (2013) Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons. PLoS One 8 e60365 PMID: 23565235
Jahchan et al (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov 3 1364 PMID: 24078773
Chen et al (2012) Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem 287 5059 PMID: 22184108
Hampson et al (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 50 1743 PMID: 17579833
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.