Rivastigmine tartrate

Cat. No. 4440 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Dual AChE and BChE inhibitor

别名： ENA 713

化学名： N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester (2R,3R)-2,3-dihydroxybutanedioate

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Rivastigmine tartrate

Rivastigmine tartrate is a cholinesterase inhibitor; inhibits both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC₅₀ ranges are 4.3-4760 nM and 16-238 nM respectively). Rivastigmine increases α-secretase activity and directs APP processing to the non-amyloidogenic pathway. Brain penetrant.

化合物库 for Rivastigmine tartrate

Rivastigmine tartrate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Rivastigmine tartrate

分子量	400.42
公式	C₁₄H₂₂N₂O₂.C₄H₆O₆
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	129101-54-8
PubChem ID	6918078
InChI Key	GWHQHAUAXRMMOT-MBANBULQSA-N
Smiles	O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Rivastigmine tartrate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	40.04	100
	DMSO	40.04	100

制备储备液 for Rivastigmine tartrate

以下数据基于产品分子量 400.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.5 mL	12.49 mL	24.97 mL
5 mM	0.5 mL	2.5 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.5 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

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产品说明书 for Rivastigmine tartrate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Rivastigmine tartrate

参考文献是支持产品生物活性的出版物。

Groner et al (2007) The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 71 1610 PMID: 17347320

Luo et al (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 49 2174 PMID: 16570913

Mehta et al (2012) New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis PMID: 22216416

Bailey et al (2011) Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 6 e21954 PMID: 21799757

Brus et al (2014) J.Med.Chem. 57 8167 PMID: 25226236

If you know of a relevant reference for Rivastigmine tartrate, please let us know.

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1 篇 Rivastigmine tartrate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Rivastigmine tartrate 的部分引用包括：

Budzynska et al (2015) Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice. Curr Alzheimer Res 232 931 PMID: 25189792

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