RN 1747

Cat. No. 3745 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective TRPV4 agonist

化学名： 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

纯度： ≥98% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for RN 1747

RN 1747 is a selective TRPV4 agonist (EC₅₀ values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC₅₀ values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC₅₀ = 4 μM).

化合物库 for RN 1747

RN 1747 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for RN 1747

分子量	395.87
公式	C₁₇H₁₈ClN₃O₄S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1024448-59-6
PubChem ID	5068295
InChI Key	ZNLVYSJQUMALEO-UHFFFAOYSA-N
Smiles	ClC1=CC=C(S(N2CCN(CC3=CC=CC=C3)CC2)(=O)=O)C([N+]([O-])=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RN 1747

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	39.59	100

制备储备液 for RN 1747

以下数据基于产品分子量 395.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.63 mL	25.26 mL
5 mM	0.51 mL	2.53 mL	5.05 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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产品说明书 for RN 1747

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RN 1747

参考文献是支持产品生物活性的出版物。

Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490 PMID: 19737537

If you know of a relevant reference for RN 1747, please let us know.

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关键词: RN 1747, RN 1747 supplier, RN1747, selective, TRPV4, agonists, transient, receptors, potential, channels, vanilloid, TRPV, 3745, Tocris Bioscience