RN 1747

Name: RN 1747
Brand: Tocris Bioscience
SKU: 3745

Cat. No. 3745 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3745 has been discontinued.

View all TRPV Channels products.

说明： Selective TRPV4 agonist

化学名： 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

纯度： ≥98% (HPLC)

说明书

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for RN 1747

RN 1747 is a selective TRPV4 agonist (EC₅₀ values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC₅₀ values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC₅₀ = 4 μM).

化合物库 for RN 1747

RN 1747 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for RN 1747

分子量	395.87
公式	C₁₇H₁₈ClN₃O₄S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1024448-59-6
PubChem ID	5068295
InChI Key	ZNLVYSJQUMALEO-UHFFFAOYSA-N
Smiles	ClC1=CC=C(S(N2CCN(CC3=CC=CC=C3)CC2)(=O)=O)C([N+]([O-])=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for RN 1747

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RN 1747

参考文献是支持产品生物活性的出版物。

Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490 PMID: 19737537

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关键词: RN 1747, RN 1747 supplier, RN1747, selective, TRPV4, agonists, transient, receptors, potential, channels, vanilloid, TRPV, 3745, Tocris Bioscience