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Submit ReviewRo 04-5595 hydrochloride
说明： GluN2B-selective NMDA antagonist
化学名： 1-[2-(4-Chlorophenyl)ethyl]-1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinol hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Ro 04-5595 hydrochloride
Ro 04-5595 hydrochloride is a selective antagonist for GluN2B (formally NR2B) containing NMDA receptors (Ki = 31 nM).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for Ro 04-5595 hydrochloride
| 分子量 | 368.3 |
| 公式 | C19H22ClNO2.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 64047-73-0 |
| PubChem ID | 46739 |
| InChI Key | NVIPBLQAFKRFSZ-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC2=C(C=C1O)C(CCC1=CC=C(Cl)C=C1)N(C)CC2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ro 04-5595 hydrochloride
参考文献 for Ro 04-5595 hydrochloride
参考文献是支持产品生物活性的出版物。
Mutel et al (1998) In vitro binding properties in rat brain of [3H] Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J.Neurochem. 70 214
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关键词: Ro 04-5595 hydrochloride, Ro 04-5595 hydrochloride supplier, Selective, NR2B, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Ro04-5595, hydrochloride, GluN2B, 2005, Tocris Bioscience
1 篇 Ro 04-5595 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ro 04-5595 hydrochloride 的部分引用包括：
Voyer (2017) Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors Neuropharmacology 112 150 PMID: 27267684
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