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Submit ReviewRo 10-5824 dihydrochloride
说明： Selective D4 partial agonist
化学名： 5-[(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)methyl]-2-methyl-4-pyrimidinamine dihydrochloride
纯度： ≥99% (HPLC)
生物活性 for Ro 10-5824 dihydrochloride
Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM). Displays 250-fold selectivity over D3 receptors and > 1000-fold selectivity over D2, D1 and D5 receptors.
技术数据 for Ro 10-5824 dihydrochloride
| 分子量 | 353.29 |
| 公式 | C17H20N4.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 189744-94-3 |
| PubChem ID | 16759174 |
| InChI Key | UZHMRJRDYCRKIZ-UHFFFAOYSA-N |
| Smiles | Cl.Cl.CC1=NC=C(CN2CCC(=CC2)C2=CC=CC=C2)C(N)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ro 10-5824 dihydrochloride
参考文献 for Ro 10-5824 dihydrochloride
参考文献是支持产品生物活性的出版物。
Powell et al (2003) RO-10-5824 is a selective DA D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology 44 473 PMID: 12646284
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关键词: Ro 10-5824 dihydrochloride, Ro 10-5824 dihydrochloride supplier, Selective, D4, receptor, partial, agonists, Dopamine, Receptors, dopaminergic, Ro10-5824, dihydrochloride, 2329, Tocris Bioscience
1 篇 Ro 10-5824 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ro 10-5824 dihydrochloride 的部分引用包括：
Navakkode et al (2017) Bidirectional modulation of hippocampal synaptic plasticity by Dopaminergic D4-receptors in the CA1 area of hippocampus. Sci Rep 7 15571 PMID: 29138490
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.